SeyedAlinaghi SeyedAhmad, Oliaei Shahram, Kianzad Shaghayegh, Afsahi Amir Masoud, MohsseniPour Mehrzad, Barzegary Alireza, Mirzapour Pegah, Behnezhad Farzane, Noori Tayebeh, Mehraeen Esmaeil, Dadras Omid, Voltarelli Fabricio, Sabatier Jean-Marc
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran 1586489615, Iran.
HBOT Research Center, Golestan Hospital, Islamic Republic of Iran, Navy and AJA Medical University, Tehran 7134845794, Iran.
World J Virol. 2020 Dec 15;9(5):79-90. doi: 10.5501/wjv.v9.i5.79.
There is recently a concern regarding the reinfection and reactivation of previously reCoVered coronavirus disease 2019 (CoVID-19) patients.
To summarize the recent findings and reports of CoVID-19 reinfection in patients previously reCoVered from the disease.
This study was a systematic review of current evidence conducted in August 2020. The authors studied the probable reinfection risk of novel coronavirus (CoVID-19). We performed a systematic search using the keywords in online databases. The investigation adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist to ensure the reliability and validity of this study and results.
We reviewed 31 studies. Eight studies described reCoVered patients with reinfection. Only one study reported reinfected patients who died. In 26 studies, there was no information about the status of the patients. Several studies indicated that reinfection is not probable and that post-infection immunity is at least temporary and short.
Based on our review, we concluded that a positive polymerase chain reaction retest could be due to several reasons and should not always be considered as reinfection or reactivation of the disease. Most relevant studies in positive retest patients have shown relative and probably temporary immunity after the reCoVery of the disease.
最近，人们对先前康复的2019冠状病毒病（COVID-19）患者的再次感染和病毒再激活表示关注。
总结先前从COVID-19疾病中康复的患者再次感染的最新研究结果和报告。
本研究是对2020年8月现有证据进行的系统评价。作者研究了新型冠状病毒（COVID-19）可能的再次感染风险。我们使用在线数据库中的关键词进行了系统检索。调查遵循系统评价和Meta分析的首选报告项目（PRISMA）清单，以确保本研究及结果的可靠性和有效性。
我们回顾了31项研究。八项研究描述了康复患者的再次感染情况。只有一项研究报告了再次感染后死亡的患者。在26项研究中，没有关于患者状况的信息。几项研究表明，再次感染不太可能发生，感染后免疫力至少是暂时的且持续时间较短。
根据我们的综述，我们得出结论，聚合酶链反应复测呈阳性可能有多种原因，不应总是被视为疾病的再次感染或再激活。大多数关于复测呈阳性患者的相关研究表明，疾病康复后存在相对且可能是暂时的免疫力。
