Department of Infection Disease and Clinical Microbiology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Department of Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.
Int J Clin Pract. 2021 Nov;75(11):e14728. doi: 10.1111/ijcp.14728. Epub 2021 Aug 21.
Severe disease characterised by interstitial pneumonia may develop in some cases of coronavirus disease (COVID-19). Periostin has been associated with many respiratory diseases. In this study, we aimed to investigate whether periostin could be a useful new biomarker in the follow-up and severity assessment of the disease in patients with COVID-19 pneumonia.
In the study, 32 patients followed up during May to July 2020 because of COVID-19 and 24 healthy controls were included. The patients were divided into two groups, namely, mild/moderate and severe, according to the severity of the disease. Serum periostin and transforming growth factor beta (TGF-β) levels were tested using an enzyme-linked immunosorbent assay (ELISA) method using commercially available ELISA kits.
It was observed that the periostin level was significantly higher in both mild/moderate cases and severe cases compared with the control group at first presentation. However, TGF-β levels at first presentation were similar between the groups.
The current manuscript may be the first one performing periostin ELISA on COVID serum, and we believe that periostin can be used as a new biomarker.
某些情况下，冠状病毒病（COVID-19）可发展为以间质性肺炎为特征的严重疾病。骨膜蛋白与许多呼吸系统疾病有关。本研究旨在探讨骨膜蛋白是否可作为 COVID-19 肺炎患者疾病随访和严重程度评估的一种有用的新型生物标志物。
本研究纳入了 2020 年 5 月至 7 月期间因 COVID-19 接受随访的 32 例患者和 24 例健康对照者。根据疾病严重程度，患者分为轻症/普通组和重症组。采用酶联免疫吸附试验（ELISA）方法，使用市售 ELISA 试剂盒检测血清骨膜蛋白和转化生长因子β（TGF-β）水平。
首次就诊时，轻症/普通组和重症组的骨膜蛋白水平均明显高于对照组，但两组 TGF-β 水平相似。
本研究可能是首次对 COVID 血清进行骨膜蛋白 ELISA 检测，我们认为骨膜蛋白可作为一种新型生物标志物。
