Wang Jing, Hou Wan-Ting, Qin Xue-Mei, DU Guan-Hua, Gao Xiao-Xia
College of Chemistry and Chemical Engineering,Shanxi University Taiyuan 030006,China.
Modern Research Center for Traditional Chinese Medicine,Shanxi University Taiyuan 030006,China.
Zhongguo Zhong Yao Za Zhi. 2021 Jul;46(13):3240-3248. doi: 10.19540/j.cnki.cjcmm.20210308.601.
Circadian rhythm disorder is a common society issue caused by jet lag,shift work,sleep disruption and changes in food consumption. Light is the major factor affecting the circadian rhythm system. Disruption of the circadian rhythm system can cause damage to the body,leading to some diseases. Maintaining a normal circadian system is of great importance for good health. Ideal therapeutic effect can not only alleviate symptoms of the diseases,but also recovery the disturbed circadian rhythm to normal. The paper summarizes the modeling methods of animal circadian rhythm disorder,diseases of circadian rhythm abnormality,regulation of circadian clock genes and medicine which are related to circadian rhythm to diseases of circadian rhythm disorder.
昼夜节律紊乱是一种常见的社会问题，由时差、轮班工作、睡眠中断和饮食变化引起。光是影响昼夜节律系统的主要因素。昼夜节律系统的紊乱会对身体造成损害，导致一些疾病。维持正常的昼夜节律系统对身体健康至关重要。理想的治疗效果不仅可以缓解疾病症状，还能使紊乱的昼夜节律恢复正常。本文总结了动物昼夜节律紊乱的建模方法、昼夜节律异常相关疾病、生物钟基因的调控以及与昼夜节律紊乱相关疾病的药物。
