Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Breast Dis. 2022;41(1):51-54. doi: 10.3233/BD-210009.
The etiology and incidence of Fibroadenoma (FA) as the most frequent benign breast mass and uterine fibroma (UF) as the most benign gynecological disorders are unknown.
Considering the dependency of FA and UF to sex hormones, our objective was to investigate the association of these two neoplasms.
Among women attending the hospital Gynecology Clinic, those with typical uterine fibroids in their pelvic ultrasound constituted cases and those with no pathology the controls. All participants underwent breast ultrasound for FA. Criteria for diagnosis of FA were a typical image for lumps <2 cm in women aged <40 and <1 cm in ages ≥ 40, and a histologic diagnosis for all other participants or larger lumps.
The mean age of cases and controls was 42.4 and 41.7 years, respectively. FA were detected in 140 (23%) of all participants; 19.7% of the cases, and 26.2% of the controls (p = 0.07). FA and UF had a borderline reverse association (OR = 0.69, 95% CI = 0.46-1.02, p = 0.07).
The incidence of FA is lower in patients with UF. Further studies are needed to find the selective effects of estrogen and progesterone on hormonal receptors of these two tumors.
纤维腺瘤（FA）作为最常见的良性乳腺肿块和子宫肌瘤（UF）作为最常见的良性妇科疾病，其病因和发病率尚不清楚。
鉴于 FA 和 UF 依赖于性激素，我们的目的是研究这两种肿瘤之间的关联。
在就诊于医院妇科诊所的女性中，那些在盆腔超声中有典型子宫肌瘤的构成病例，而那些无病理改变的则为对照组。所有参与者都接受了乳腺超声检查以排除纤维腺瘤。FA 的诊断标准是：对于年龄<40 岁的女性，肿块典型图像<2cm，年龄≥40 岁的女性<1cm，对于所有其他参与者或更大的肿块则进行组织学诊断。
病例组和对照组的平均年龄分别为 42.4 岁和 41.7 岁。在所有参与者中，共发现 140 例（23%）FA；病例组中有 19.7%，对照组中有 26.2%（p=0.07）。FA 和 UF 之间存在边缘反向关联（OR=0.69，95%CI=0.46-1.02，p=0.07）。
UF 患者中 FA 的发病率较低。需要进一步的研究来发现雌激素和孕激素对这两种肿瘤的激素受体的选择性作用。
