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雌激素对乳腺良性肿瘤的影响及复发机制的探讨。

The impact of estrogen on benign breast tumors and exploration of recurrence mechanisms.

作者信息

Fan Zhe, Wang Huijin, Liu Yu, Yu Zongshuo, Li Jingjing, Teng Yuan

机构信息

Department of Breast and Thyroid Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Thyroid and Breast Surgery Department, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China.

出版信息

Front Oncol. 2025 Jul 9;15:1609832. doi: 10.3389/fonc.2025.1609832. eCollection 2025.

Abstract

Benign breast tumors are among the most common breast diseases affecting women, with their pathogenesis closely linked to hormonal influences, particularly estrogen. This review offers a comprehensive overview of the mechanisms through which estrogen affects benign breast tumors and examines the role of estrogen in tumor cell growth, proliferation, and apoptosis. Furthermore, this review explores the recurrence mechanisms of benign breast tumors, analyzing factors such as hormone dependence, microenvironmental influences, and genetic susceptibility. By generating relevant literature, this article aims to offer new insights into clinical treatment and prevention strategies aimed at managing benign breast tumors.

摘要

良性乳腺肿瘤是影响女性的最常见乳腺疾病之一,其发病机制与激素影响密切相关,尤其是雌激素。本综述全面概述了雌激素影响良性乳腺肿瘤的机制,并探讨了雌激素在肿瘤细胞生长、增殖和凋亡中的作用。此外,本综述还探讨了良性乳腺肿瘤的复发机制,分析了激素依赖性、微环境影响和遗传易感性等因素。通过收集相关文献,本文旨在为针对良性乳腺肿瘤的临床治疗和预防策略提供新的见解。

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