Cadre's Wards, Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, First Hospital of Jilin University, Changchun, Jilin Province, China.
Department of Respiratory Medicine, Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, First Hospital of Jilin University, Changchun, Jilin Province, China.
Medicine (Baltimore). 2021 Jul 30;100(30):e26771. doi: 10.1097/MD.0000000000026771.
This study evaluated the clinical levels of CD97 and CD55 for the differential diagnosis of pleural effusion.Pleural effusion samples were collected from 106 patients (55 tuberculous pleural effusions [TPE] and 51 malignant pleural effusions [MPE]). CD97 and CD55 levels in pleural effusions were measured by enzyme-linked immunosorbent assay.CD97 levels were significantly higher in the TPE group than in the MPE group (P < .001), while CD55 levels in the MPE group were significantly higher than the TPE group (P < .001). The sensitivity and specificity of CD97 testing for the differential diagnosis of TPE and MPE was 80.0% and 60.8%, respectively, while the sensitivity and specificity of CD55 testing for TPE and MPE was 88.2% and 85.5%, respectively. Furthermore, the sensitivity and specificity of combinatorial CD97 and CD55 testing for TPE and MPE was 90.0% and 87.5%, respectively. Moreover, CD97 and CD55 were negatively correlated in the MPE group (r = -0.383, P = .005), while no correlations were observed in the TPE group. CD97 or CD55 showed no correlations with other inflammatory cytokines (tumor necrosis factor α, interleukin 1β, erythrocyte sedimentation rate, and C-reactive protein) in both groups (P > .05).CD97 and CD55 may be used as biological markers for the differential diagnosis of pleural effusion in clinical settings.
本研究评估了 CD97 和 CD55 在胸腔积液鉴别诊断中的临床水平。收集了 106 例患者的胸腔积液样本（55 例结核性胸腔积液[TPE]和 51 例恶性胸腔积液[MPE]）。通过酶联免疫吸附试验测量胸腔积液中的 CD97 和 CD55 水平。TPE 组的 CD97 水平明显高于 MPE 组（P<0.001），而 MPE 组的 CD55 水平明显高于 TPE 组（P<0.001）。CD97 检测用于 TPE 和 MPE 鉴别诊断的敏感性和特异性分别为 80.0%和 60.8%，而 CD55 检测用于 TPE 和 MPE 的敏感性和特异性分别为 88.2%和 85.5%。此外，CD97 和 CD55 联合检测用于 TPE 和 MPE 的敏感性和特异性分别为 90.0%和 87.5%。此外，MPE 组中 CD97 和 CD55 呈负相关（r=-0.383，P=0.005），而 TPE 组中无相关性。在两组中，CD97 或 CD55 与其他炎症细胞因子（肿瘤坏死因子-α、白细胞介素 1β、红细胞沉降率和 C 反应蛋白）均无相关性（P>0.05）。CD97 和 CD55 可作为胸腔积液鉴别诊断的生物标志物在临床环境中使用。
