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脂质体包裹制霉菌素作为系统性念珠菌病治疗剂的制剂、毒性及体外抗真菌活性

Formulation, toxicity, and antifungal activity in vitro of liposome-encapsulated nystatin as therapeutic agent for systemic candidiasis.

作者信息

Mehta R T, Hopfer R L, Gunner L A, Juliano R L, Lopez-Berestein G

机构信息

Department of Clinical Immunology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston.

出版信息

Antimicrob Agents Chemother. 1987 Dec;31(12):1897-900. doi: 10.1128/AAC.31.12.1897.

DOI:10.1128/AAC.31.12.1897
PMID:3439798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC175823/
Abstract

Multilamellar vesicles containing nystatin (NYS) were compared with vesicles containing the free drug for toxicity to erythrocytes and for antifungal activity in vitro. Liposomal nystatin was as active as free NYS was against a wide variety of yeasts and fungi. The antifungal activity against Candida albicans was maintained with different liposome compositions and without sterols. Liposome encapsulation also protected the erythrocytes from the toxicity of free NYS.

摘要

将含有制霉菌素（NYS）的多层囊泡与含有游离药物的囊泡在体外对红细胞的毒性和抗真菌活性方面进行了比较。脂质体制霉菌素与游离NYS对多种酵母和真菌的活性相同。在不同的脂质体组成且无甾醇的情况下，对白色念珠菌的抗真菌活性得以维持。脂质体包封还保护红细胞免受游离NYS的毒性影响。

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本文引用的文献

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The action of pimaricin, etruscomycin and amphotericin B on liposomes with varying sterol content.匹马霉素、伊曲古霉素和两性霉素B对不同固醇含量脂质体的作用。
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Toxicity and therapeutic effects in mice of liposome-encapsulated nystatin for systemic fungal infections.脂质体包裹制霉菌素对小鼠系统性真菌感染的毒性及治疗作用
Antimicrob Agents Chemother. 1987 Dec;31(12):1901-3. doi: 10.1128/AAC.31.12.1901.