游离型和脂质体包裹型制霉菌素与四种两性霉素B制剂的体外抗真菌活性比较。
Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.
作者信息
Johnson E M, Ojwang J O, Szekely A, Wallace T L, Warnock D W
机构信息
Mycology Reference Laboratory, Public Health Laboratory Service, Bristol, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1998 Jun;42(6):1412-6. doi: 10.1128/AAC.42.6.1412.
The in vitro activity of a multilamellar liposomal formulation of nystatin (Nyotran) was compared with those of free nystatin and four pharmaceutical preparations of amphotericin B. MICs for 200 isolates of two Aspergillus spp., seven Candida spp., and Cryptococcus neoformans were determined by a broth microdilution adaptation of the method recommended by the National Committee for Clinical Laboratory Standards. Minimum lethal concentrations (MLCs) of the six antifungal preparations were also determined. Both nystatin formulations possessed fungistatic and fungicidal activities against the 10 species tested. Liposomal nystatin appeared to be as active as free nystatin, with MICs and MLCs that were similar to, or lower than, those of the latter. Neither formulation of nystatin was as active as amphotericin B deoxycholate (Fungizone) or amphotericin B lipid complex (Abelcet), but both were more effective than liposomal amphotericin B (AmBisome). Our results suggest that further evaluation of liposomal nystatin is justified.
将制霉菌素的多层脂质体制剂（尼可罗）的体外活性与游离制霉菌素以及两性霉素B的四种药物制剂进行了比较。采用美国国家临床实验室标准委员会推荐方法的肉汤微量稀释法，测定了200株两种曲霉菌、七种念珠菌和新型隐球菌的最低抑菌浓度（MIC）。还测定了六种抗真菌制剂的最低致死浓度（MLC）。两种制霉菌素制剂对所测试的10种菌种均具有抑菌和杀菌活性。脂质体制霉菌素似乎与游离制霉菌素活性相当，其MIC和MLC与后者相似或更低。两种制霉菌素制剂的活性均不如两性霉素B脱氧胆酸盐（Fungizone）或两性霉素B脂质复合物（Abelcet），但两者均比脂质体两性霉素B（安必素）更有效。我们的结果表明，对脂质体制霉菌素进行进一步评估是合理的。
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