通过闭胸大鼠冠状动脉结扎法对有机溶剂进行心脏毒性测试。
Cardiotoxicity testing of organic solvents by coronary artery ligation in closed-chest rats.
作者信息
Hoffmann P
机构信息
Institute of Industrial Toxicology, Martin Luther University Halle, German Democratic Republic.
出版信息
Arch Toxicol. 1987;61(1):79-82. doi: 10.1007/BF00324553.
The effect in coronary artery occlusion was investigated in closed-chest anesthetized (urethane, pentobarbital, ether) and conscious rats. The parameters measured were: arrhythmia development, heart rate changes and mortality. Lowest mortality rate and less severe arrhythmias were observed in the urethane group. In urethane-anesthetized rats single oral administration of carbon disulphide (8.3 mmol/kg), chloroform (5.7 mmol/kg), trichloroethylene (16.7 mmol/kg) and ethanol (174 mmol/kg), respectively, 1 h prior to coronary occlusion reduced survival rate accompanied by marked influences on arrhythmia development. The coronary occlusion method in closed-chest rats under urethane-anesthesia appears to be a valuable tool for investigating cardiotoxic effects of chemicals.
在闭胸麻醉（氨基甲酸乙酯、戊巴比妥、乙醚）和清醒的大鼠中研究了冠状动脉闭塞的影响。所测量的参数为：心律失常的发生、心率变化和死亡率。在氨基甲酸乙酯组中观察到最低的死亡率和不太严重的心律失常。在氨基甲酸乙酯麻醉的大鼠中，冠状动脉闭塞前1小时分别单次口服二硫化碳（8.3 mmol/kg）、氯仿（5.7 mmol/kg）、三氯乙烯（16.7 mmol/kg）和乙醇（174 mmol/kg），降低了存活率，并对心律失常的发生有显著影响。氨基甲酸乙酯麻醉下闭胸大鼠的冠状动脉闭塞方法似乎是研究化学物质心脏毒性作用的一种有价值的工具。
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