Hunder G, Schmid A, Mayring L
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztlichen Fakultät, Universität München, Federal Republic of Germany.
Arch Toxicol. 1987 Dec;61(2):161-3. doi: 10.1007/BF00661377.
The investigation was aimed at providing insight into the side chain metabolism of furazolidone in mice. The agents used in the experiments were furazolidone, 3-amino-2-oxazolidinone, oxazolidinone, nitrofurantoin, 3-aminohydantoin and hydantoin, administered intraperitoneally at five equimolar doses ranging from 0.178 to 0.888 mmol/kg. The parameters investigated included ethane and ethylene expiration, formation of malondialdehyde and total glutathione content in the liver. Ethylene expiration was found to be strongly enhanced by aminooxazolidinone and slightly increased by furazolidone. Ethane expiration was increased after aminooxazolidinone administration. Malondialdehyde formation was not affected by any of the agents used. Total glutathione was decreased by furazolidone and nitrofurantoin. The above findings indicate that, in vivo, the azomethine linkage of the side chain of furazolidone hydrolyses to form 3-amino-2-oxazolidinone, subsequently cleaved to ethylene.
该研究旨在深入了解呋喃唑酮在小鼠体内的侧链代谢情况。实验中使用的药物有呋喃唑酮、3-氨基-2-恶唑烷酮、恶唑烷酮、呋喃妥因、3-氨基乙内酰脲和乙内酰脲，以0.178至0.888 mmol/kg的五个等摩尔剂量腹腔注射。所研究的参数包括乙烷和乙烯呼出量、肝脏中丙二醛的形成以及总谷胱甘肽含量。发现氨基恶唑烷酮可强烈增强乙烯呼出量，呋喃唑酮可使其略有增加。给予氨基恶唑烷酮后乙烷呼出量增加。所使用的任何药物均未影响丙二醛的形成。呋喃唑酮和呋喃妥因可降低总谷胱甘肽含量。上述研究结果表明，在体内，呋喃唑酮侧链的甲亚胺键水解形成3-氨基-2-恶唑烷酮，随后裂解为乙烯。
