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吲哚洛尔对血清脂蛋白影响的长期研究:初步报告。

A long-term study on the effect of pindolol on serum lipoproteins: a preliminary report.

作者信息

Carlson L A, Ribacke M, Terent A

机构信息

King Gustaf V Research Institute, Department of Internal Medicine, Karolinska Hospital, Stockholm.

出版信息

Br J Clin Pharmacol. 1987;24 Suppl 1(Suppl 1):61S-62S. doi: 10.1111/j.1365-2125.1987.tb03272.x.

DOI:10.1111/j.1365-2125.1987.tb03272.x
PMID:3440110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386212/
Abstract
  1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months treatment. After 6 months treatment 35/47 patients had attained the target blood pressure of less than or equal to 95 mm Hg and analysis of plasma lipid and lipoprotein concentrations revealed a tendency for an increase of serum triglycerides and a lowering of low density lipoprotein cholesterol.
摘要
  1. 一项长期研究报告了初步结果,该研究旨在记录使用吲哚洛尔治疗6个月、12个月和24个月的中青年中度高血压男性患者的血脂和脂蛋白浓度。2. 已招募73名患者,其中47名完成了6个月的治疗。治疗6个月后,47名患者中有35名达到了目标血压,即小于或等于95毫米汞柱,血浆脂质和脂蛋白浓度分析显示血清甘油三酯有升高趋势,低密度脂蛋白胆固醇有降低趋势。

相似文献

1
A long-term study on the effect of pindolol on serum lipoproteins: a preliminary report.吲哚洛尔对血清脂蛋白影响的长期研究:初步报告。
Br J Clin Pharmacol. 1987;24 Suppl 1(Suppl 1):61S-62S. doi: 10.1111/j.1365-2125.1987.tb03272.x.
2
Effects of pindolol on serum lipids, apolipoproteins, and lipoproteins in patients with mild to moderate essential hypertension.吲哚洛尔对轻至中度原发性高血压患者血脂、载脂蛋白及脂蛋白的影响。
Clin Ther. 1989 Mar-Apr;11(2):219-24.
3
Long-term effect of pindolol on lipids and lipoproteins in men with newly diagnosed hypertension.
Eur J Clin Pharmacol. 1989;36(4):347-50. doi: 10.1007/BF00558293.
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Effect of metoprolol and pindolol monotherapy on plasma lipid- and lipoprotein-cholesterol levels (including the HDL subclasses) in mild hypertensive males and females.
J Cardiovasc Pharmacol. 1990 Jun;15(6):911-7. doi: 10.1097/00005344-199006000-00008.
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Effects of pindolol and metoprolol on plasma lipids and lipoproteins.吲哚洛尔和美托洛尔对血脂及脂蛋白的影响。
Br J Clin Pharmacol. 1982;13(Suppl 2):435S-439S. doi: 10.1111/j.1365-2125.1982.tb01953.x.
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Effects of short term beta adrenoreceptor blockade on serum lipids and lipoproteins in patients with hypertension or coronary artery disease.短期β-肾上腺素能受体阻滞剂对高血压或冠状动脉疾病患者血脂和脂蛋白的影响。
Br Heart J. 1984 Jun;51(6):589-94. doi: 10.1136/hrt.51.6.589.
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Reversal of diuretic-induced increases in serum low-density-lipoprotein cholesterol by the betablocker pindolol.β受体阻滞剂吲哚洛尔可逆转利尿剂引起的血清低密度脂蛋白胆固醇升高。
Metabolism. 1982 Apr;31(4):411-5. doi: 10.1016/0026-0495(82)90119-6.
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Effect of pindolol on changes in serum lipids induced by hydrochlorthiazide.
Eur J Clin Pharmacol. 1989;37(3):221-3. doi: 10.1007/BF00679773.
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Long-term effects of pindolol and a thiazide diuretic on plasma lipids and blood pressure in patients with essential hypertension.吲哚洛尔与噻嗪类利尿剂对原发性高血压患者血脂及血压的长期影响
J Hum Hypertens. 1990 Aug;4(4):453-7.
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Metabolic effects of isradipine as monotherapy or in combination with pindolol during long-term antihypertensive treatment.在长期抗高血压治疗期间,伊拉地平单药治疗或与吲哚洛尔联合使用的代谢效应。
J Intern Med. 1994 Jul;236(1):37-42. doi: 10.1111/j.1365-2796.1994.tb01117.x.

本文引用的文献

1
Thiazide-induced disturbances in carbohydrate, lipid, and potassium metabolism.噻嗪类药物引起的碳水化合物、脂质和钾代谢紊乱。
Am Heart J. 1983 Jul;106(1 Pt 2):245-51. doi: 10.1016/0002-8703(83)90124-2.
2
High-density lipoproteins: epidemiologic profile and risks of coronary artery disease.高密度脂蛋白:流行病学概况与冠状动脉疾病风险
Am J Cardiol. 1983 Aug 22;52(4):9B-12B. doi: 10.1016/0002-9149(83)90649-5.
3
The large studies in hypertension: what have they shown?高血压方面的大型研究:它们表明了什么?
Br J Clin Pharmacol. 1987;24 Suppl 1(Suppl 1):3S-14S. doi: 10.1111/j.1365-2125.1987.tb03262.x.
4
Treatment of high blood pressure: should clinical practice be based on results of clinical trials?高血压的治疗:临床实践应基于临床试验结果吗?
Br Med J (Clin Res Ed). 1986 Aug 16;293(6544):433-7. doi: 10.1136/bmj.293.6544.433.