吲哚洛尔和美托洛尔对血脂及脂蛋白的影响。
Effects of pindolol and metoprolol on plasma lipids and lipoproteins.
作者信息
Pasotti C, Capra A, Fiorella G, Vibelli C, Chierichetti S M
出版信息
Br J Clin Pharmacol. 1982;13(Suppl 2):435S-439S. doi: 10.1111/j.1365-2125.1982.tb01953.x.
1 The effects of two beta-adrenoceptor blocking drugs, pindolol and metoprolol, on plasma lipids and lipoproteins were studied in sixteen hypertensive patients (WHO I-I) by a cross-over design, with two active treatment periods of 12 weeks each. 2 Neither pindolol nor metoprolol had any effect on total plasma cholesterol (total-C), triglycerides (TG) or low-density lipoprotein cholesterol (LDL-C). 3 Pindolol significantly increased high-density lipoprotein cholesterol (HDL-C). After metoprolol, HDL-C levels remained similar to those in the placebo period. 4 The ratio of total-C to HDL-C was significantly reduced by pindolol only. 5 Compared with the placebo period, both pindolol and metoprolol significantly reduced heart rate (HR) and systolic (SBP) and diastolic (DBP) blood pressure. The decreases in HR were significantly greater after metoprolol. No differences between the effects of the two drugs on SBP and/or DBP were observed.
采用交叉设计，对16例高血压患者（WHO I-I级）研究了两种β-肾上腺素能受体阻滞剂吲哚洛尔和美托洛尔对血浆脂质和脂蛋白的影响，每个活性治疗期为12周。
吲哚洛尔和美托洛尔对血浆总胆固醇（total-C）、甘油三酯（TG）或低密度脂蛋白胆固醇（LDL-C）均无影响。
吲哚洛尔显著升高高密度脂蛋白胆固醇（HDL-C）。服用美托洛尔后，HDL-C水平与安慰剂期相似。
仅吲哚洛尔使总胆固醇与HDL-C的比值显著降低。
与安慰剂期相比，吲哚洛尔和美托洛尔均显著降低心率（HR）、收缩压（SBP）和舒张压（DBP）。美托洛尔治疗后心率下降幅度更大。未观察到两种药物对SBP和/或DBP的影响有差异。
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