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1
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Br J Clin Pharmacol. 1982;13(Suppl 2):435S-439S. doi: 10.1111/j.1365-2125.1982.tb01953.x.
2
Effect of metoprolol and pindolol monotherapy on plasma lipid- and lipoprotein-cholesterol levels (including the HDL subclasses) in mild hypertensive males and females.
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3
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4
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引用本文的文献

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Eur J Clin Pharmacol. 1984;26(3):331-4. doi: 10.1007/BF00548763.
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Drugs. 1986 Oct;32(4):335-57. doi: 10.2165/00003495-198632040-00003.
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The effects of diuretics and adrenergic-blocking agents on plasma lipids.利尿剂和肾上腺素能阻滞剂对血浆脂质的影响。
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本文引用的文献

1
The effect of metoprolol and atenolol on plasma high density lipoprotein levels in man.美托洛尔和阿替洛尔对人体血浆高密度脂蛋白水平的影响。
Clin Exp Pharmacol Physiol. 1980 May-Jun;7(3):329-33. doi: 10.1111/j.1440-1681.1980.tb00078.x.
2
Epidemiology as a guide to clinical decisions. The association between triglyceride and coronary heart disease.作为临床决策指南的流行病学。甘油三酯与冠心病之间的关联。
N Engl J Med. 1980 Jun 19;302(25):1383-9. doi: 10.1056/NEJM198006193022503.
3
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.无需使用制备性超速离心机来估算血浆中低密度脂蛋白胆固醇的浓度。
Clin Chem. 1972 Jun;18(6):499-502.
4
Effects of metoprolol and propranolol on lipid metabolism.
Int J Clin Pharmacol Biopharm. 1979 Sep;17(9):378-82.
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Long-term effect of sotalol on plasma lipids.
Clin Sci (Lond). 1979 Dec;57 Suppl 5:405s-407s. doi: 10.1042/cs057405s.
6
High density lipoprotein cholesterol and incidence of coronary heart disease--the Israeli Ischemic Heart Disease Study.高密度脂蛋白胆固醇与冠心病发病率——以色列缺血性心脏病研究
Am J Epidemiol. 1979 Mar;109(3):296-308. doi: 10.1093/oxfordjournals.aje.a112683.
7
Effect of propranolol on HDL cholesterol concentrations.普萘洛尔对高密度脂蛋白胆固醇浓度的影响。
Br Med J. 1978 Nov 25;2(6150):1495. doi: 10.1136/bmj.2.6150.1495-b.
8
High-density lipoprotein cholesterol and antihypertensive drugs: the Oslo study.高密度脂蛋白胆固醇与抗高血压药物：奥斯陆研究
Br Med J. 1978 Aug 5;2(6134):403. doi: 10.1136/bmj.2.6134.403.
9
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study.高密度脂蛋白作为冠心病的保护因素。弗明汉姆研究。
Am J Med. 1977 May;62(5):707-14. doi: 10.1016/0002-9343(77)90874-9.
10
HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study.高密度脂蛋白胆固醇及其他脂质与冠心病。合作脂蛋白表型研究。
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吲哚洛尔和美托洛尔对血脂及脂蛋白的影响。

Effects of pindolol and metoprolol on plasma lipids and lipoproteins.

作者信息

Pasotti C, Capra A, Fiorella G, Vibelli C, Chierichetti S M

出版信息

Br J Clin Pharmacol. 1982;13(Suppl 2):435S-439S. doi: 10.1111/j.1365-2125.1982.tb01953.x.

DOI:10.1111/j.1365-2125.1982.tb01953.x
PMID:7104157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1402179/
Abstract

1 The effects of two beta-adrenoceptor blocking drugs, pindolol and metoprolol, on plasma lipids and lipoproteins were studied in sixteen hypertensive patients (WHO I-I) by a cross-over design, with two active treatment periods of 12 weeks each. 2 Neither pindolol nor metoprolol had any effect on total plasma cholesterol (total-C), triglycerides (TG) or low-density lipoprotein cholesterol (LDL-C). 3 Pindolol significantly increased high-density lipoprotein cholesterol (HDL-C). After metoprolol, HDL-C levels remained similar to those in the placebo period. 4 The ratio of total-C to HDL-C was significantly reduced by pindolol only. 5 Compared with the placebo period, both pindolol and metoprolol significantly reduced heart rate (HR) and systolic (SBP) and diastolic (DBP) blood pressure. The decreases in HR were significantly greater after metoprolol. No differences between the effects of the two drugs on SBP and/or DBP were observed.

摘要

  1. 采用交叉设计，对16例高血压患者（WHO I-I级）研究了两种β-肾上腺素能受体阻滞剂吲哚洛尔和美托洛尔对血浆脂质和脂蛋白的影响，每个活性治疗期为12周。

  2. 吲哚洛尔和美托洛尔对血浆总胆固醇（total-C）、甘油三酯（TG）或低密度脂蛋白胆固醇（LDL-C）均无影响。

  3. 吲哚洛尔显著升高高密度脂蛋白胆固醇（HDL-C）。服用美托洛尔后，HDL-C水平与安慰剂期相似。

  4. 仅吲哚洛尔使总胆固醇与HDL-C的比值显著降低。

  5. 与安慰剂期相比，吲哚洛尔和美托洛尔均显著降低心率（HR）、收缩压（SBP）和舒张压（DBP）。美托洛尔治疗后心率下降幅度更大。未观察到两种药物对SBP和/或DBP的影响有差异。