Research Centre for Anthropology and Health (CIAS), Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
High School of Education, Polytechnic Institute of Viseu, Viseu, Portugal.
Arch Physiol Biochem. 2022 Dec;128(6):1510-1515. doi: 10.1080/13813455.2020.1779312. Epub 2020 Jun 18.
To investigate the association of polymorphisms in and genes with obesity indices in children.
A total of 637 Portuguese children (317 girls; 320 boys) aged 3-11 years-old were genotyped for the polymorphisms, 5-HTTLPR and STin2, and for a VNTR. Polymorphisms were analysed by PCR-based methods.
Although non-significant ( = .089), our study revealed the Stin2 10 minor allele with a marked higher frequency in girls with overweight/obesity (0.466) in comparison with controls (0.376). Combining the two polymorphisms, haplotype S/12 revealed in girls significant or nominally significant protective effects against BMI (β = -0.615; = .009), BMI Z-score (β = -0.251; = .006), WC (β = -1.4; = .02) and WHtR (β = -0.008; = .04).
We found some evidences for the role of gene in measures of childhood obesity, mainly in girls.
研究 和 基因多态性与儿童肥胖指数的相关性。
共对 637 名 3-11 岁的葡萄牙儿童（317 名女孩；320 名男孩）进行了 多态性、5-HTTLPR 和 STin2 以及 VNTR 的基因分型。采用基于 PCR 的方法分析多态性。
尽管无统计学意义（ = .089），但我们的研究表明，超重/肥胖女孩（0.466）携带 Stin2 10 次要等位基因的频率明显高于对照组（0.376）。将这两种 多态性组合在一起，S/12 单倍型在女孩中对 BMI（β = -0.615； = .009）、BMI Z 评分（β = -0.251； = .006）、WC（β = -1.4； = .02）和 WHtR（β = -0.008； = .04）具有显著或名义上的保护作用。
我们发现 基因在儿童肥胖测量中的作用的一些证据，主要在女孩中。
