Villgran V D, Rabold E, Nasrullah A, Disilvio B, Bajwa O
Pulmonary & Critical Care Medicine, Allegheny Health Network, Pittsburgh, PA, United States.
Internal Medicine, Allegheny Health Network, Pittsburgh, PA, United States.
Respir Med Case Rep. 2021 Jul 7;33:101468. doi: 10.1016/j.rmcr.2021.101468. eCollection 2021.
Pneumonitis from leflunomide is uncommon due to leflunomide's relatively favorable drug profile. Leflunomide-induced pneumonitis (LEIP) is a rare condition reported mainly in Asia. We present a case of LEIP from an accidental leflunomide overdose in the setting of concomitant methotrexate use and no underlying lung disease. Our patient was treated successfully with cholestyramine and steroids. Due to its high mortality, clinicians should be aware of this condition and its treatment.
由于来氟米特相对良好的药物特性，来氟米特引起的肺炎并不常见。来氟米特诱发的肺炎（LEIP）是一种罕见疾病，主要在亚洲有报道。我们报告了1例在同时使用甲氨蝶呤且无潜在肺部疾病的情况下因意外过量服用来氟米特导致的LEIP病例。我们的患者通过考来烯胺和类固醇成功治愈。鉴于其高死亡率，临床医生应了解这种疾病及其治疗方法。
