Kavukcu Serdar Batıkan, Çakır Sinem, Karaer Aslıhan, Türkmen Hayati, Rethinam Senthil
Science Faculty, Chemistry Department, Ege University, 35100, Bornova, Izmir, Turkey.
School of Natural and Applied Science, Ege University, 35100, Bornova, Izmir, Turkey.
Toxicol Rep. 2021 Aug 2;8:1475-1479. doi: 10.1016/j.toxrep.2021.07.018. eCollection 2021.
It is possible to reveal the potential of water-insoluble drugs by increasing their solubility in water with some nanotechnology techniques. Nanosuspension technology can solve this problem by increasing the water solubility and as well as bioavailability of these drugs. The present work is pointed at the evaluation of nanosuspension of curcumin, a poorly water-soluble drug. The Curcumin nanoparticules (CNs) were prepared with ultrasonnication method using dichloromethane as solvent and water as antisolvent and characterized spectroscopic methods (UV-vis and FT-IR) and Scanning Electron Microscopy (SEM). Curcumin nanoparticules Biofilms (CNs-BF) supported gelatin-collagen scaffold were prepared. Curcumin nanoparticles were obtained by nanosuspension technique. And then, to overcome the limited effects of curcumin such as solubility and bioavailability, nanoparticle films were prepared by incorporating it into the structure of biocompatible collagen-gelatin scaffolds. Curcumin is limited by some factors that limit its clinical applicability, such as low oral bioavailability, poor water solubility and rapid degradation. However, they can be applied clinically when they are included in the structure of biocompatible gelatin-collagen scaffolds.
通过一些纳米技术提高水不溶性药物在水中的溶解度，从而揭示其潜力是有可能的。纳米混悬液技术可以通过增加这些药物的水溶性以及生物利用度来解决这个问题。目前的工作旨在评估姜黄素纳米混悬液，姜黄素是一种水溶性差的药物。以二氯甲烷为溶剂、水为抗溶剂，采用超声法制备姜黄素纳米颗粒（CNs），并用光谱方法（紫外可见光谱和傅里叶变换红外光谱）以及扫描电子显微镜（SEM）对其进行表征。制备了负载姜黄素纳米颗粒生物膜（CNs-BF）的明胶-胶原蛋白支架。通过纳米混悬液技术获得姜黄素纳米颗粒。然后，为了克服姜黄素诸如溶解度和生物利用度等方面的局限性，将其纳入生物相容性胶原蛋白-明胶支架结构中制备纳米颗粒膜。姜黄素受到一些限制其临床应用的因素制约，如口服生物利用度低、水溶性差和快速降解。然而，当它们被纳入生物相容性明胶-胶原蛋白支架结构中时，就可以临床应用。
