产前暴露于高抗苗勒管激素建立多囊卵巢综合征小鼠模型
Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone.
机构信息
Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, 59000 Lille, France.
出版信息
STAR Protoc. 2021 Jul 31;2(3):100684. doi: 10.1016/j.xpro.2021.100684. eCollection 2021 Sep 17.
Abstract
Here, we describe a protocol that provides the steps required for the generation of a mouse model of polycystic ovary syndrome (PCOS) by exposing dams to elevated levels of anti-Müllerian hormone during late gestation. This protocol also describes the steps required to assess the PCOS-like equivalents of the Rotterdam PCOS diagnostic criteria in mice. For complete details on the use and execution of this protocol, please refer to Tata et al. (2018) and Mimouni et al. (2021).
摘要
在这里，我们描述了一种通过在妊娠后期使母鼠暴露于高水平抗苗勒管激素来产生多囊卵巢综合征（PCOS）小鼠模型的方案。该方案还描述了评估小鼠中鹿特丹 PCOS 诊断标准的 PCOS 样等效物所需的步骤。有关该方案的使用和执行的完整详细信息，请参阅 Tata 等人。（2018 年）和 Mimouni 等人。（2021 年）。
相似文献
1
Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone.产前暴露于高抗苗勒管激素建立多囊卵巢综合征小鼠模型
STAR Protoc. 2021 Jul 31;2(3):100684. doi: 10.1016/j.xpro.2021.100684. eCollection 2021 Sep 17.
2
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.孕期升高的抗苗勒氏管激素会重新编程胎儿，并导致成年后患多囊卵巢综合征。
Nat Med. 2018 Jun;24(6):834-846. doi: 10.1038/s41591-018-0035-5. Epub 2018 May 14.
3
[Anti-Mullerian hormone in the major phenotypes of polycystic ovary syndrome].[抗苗勒管激素在多囊卵巢综合征主要表型中的作用]
Akush Ginekol (Sofiia). 2014;53(5):22-7.
4
The prevalence of polycystic ovary syndrome in a normal population according to the Rotterdam criteria versus revised criteria including anti-Mullerian hormone.根据鹿特丹标准与包括抗苗勒管激素在内的修订标准，正常人群中多囊卵巢综合征的患病率。
Hum Reprod. 2014 Apr;29(4):791-801. doi: 10.1093/humrep/det469. Epub 2014 Jan 16.
5
Epigenetics suggests new perspectives for the treatment of polycystic ovary syndrome: Transgenerational effect of fetal exposure to Antimüllerian Hormone.表观遗传学为多囊卵巢综合征的治疗提供了新视角：胎儿期暴露于抗苗勒管激素的跨代效应。
Ann Endocrinol (Paris). 2021 Apr;82(2):71-73. doi: 10.1016/j.ando.2021.04.001. Epub 2021 Apr 8.
6
DIAGNOSTIC VALUE OF ANTI-MÜLLERIAN HORMONE AS A BIOMARKER FOR POLYCYSTIC OVARY SYNDROME: A META-ANALYSIS UPDATE.抗苗勒管激素作为多囊卵巢综合征生物标志物的诊断价值：一项荟萃分析更新。
Endocr Pract. 2019 Oct;25(10):1056-1066. doi: 10.4158/EP-2019-0098. Epub 2019 Aug 15.
7
Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance.多囊卵巢综合征的表观遗传传递。
Trends Mol Med. 2021 Aug;27(8):723-724. doi: 10.1016/j.molmed.2021.05.005. Epub 2021 Jun 11.
8
Use of the serum anti-Müllerian hormone assay as a surrogate for polycystic ovarian morphology: impact on diagnosis and phenotypic classification of polycystic ovary syndrome.将血清抗苗勒管激素检测作为多囊卵巢形态的替代指标：对多囊卵巢综合征的诊断和表型分类的影响。
Hum Reprod. 2017 Aug 1;32(8):1716-1722. doi: 10.1093/humrep/dex239.
9
Polycystic ovarian morphology and the diagnosis of polycystic ovary syndrome: redefining threshold levels for follicle count and serum anti-Müllerian hormone using cluster analysis.多囊卵巢形态学与多囊卵巢综合征的诊断：应用聚类分析重新定义卵泡计数和血清抗苗勒管激素的临界值。
Hum Reprod. 2017 Aug 1;32(8):1723-1731. doi: 10.1093/humrep/dex226.
10
[Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[多囊卵巢综合征女性与育龄期健康女性的血清抗苗勒管激素水平]
Akush Ginekol (Sofiia). 2013;52 Suppl 1:16-23.
引用本文的文献
1
Comparative advantage and efficacy of natural products for polycystic ovary syndrome.天然产物治疗多囊卵巢综合征的比较优势与疗效
J Ovarian Res. 2025 Aug 9;18(1):178. doi: 10.1186/s13048-025-01756-6.
2
Endocrine-disrupting chemicals and female reproductive health: a growing concern.内分泌干扰化学物质与女性生殖健康：日益受到关注。
Nat Rev Endocrinol. 2025 May 22. doi: 10.1038/s41574-025-01131-x.
3
The evolutionary basis of elevated testosterone in women with polycystic ovary syndrome: an overview of systematic reviews of the evidence.多囊卵巢综合征女性睾酮升高的进化基础：证据的系统评价概述
Front Reprod Health. 2024 Sep 30;6:1475132. doi: 10.3389/frph.2024.1475132. eCollection 2024.
本文引用的文献
1
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process.多囊卵巢综合征是通过跨代表观遗传过程传播的。
Cell Metab. 2021 Mar 2;33(3):513-530.e8. doi: 10.1016/j.cmet.2021.01.004. Epub 2021 Feb 3.
2
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.用于理解多囊卵巢综合征病因和病理生理学的动物模型
Endocr Rev. 2020 Jul 1;41(4). doi: 10.1210/endrev/bnaa010.
3
Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines.多囊卵巢综合征中的抗缪勒管激素：国际指南制定的相关综述。
Trends Endocrinol Metab. 2019 Jul;30(7):467-478. doi: 10.1016/j.tem.2019.04.006. Epub 2019 May 31.
4
Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats.通过确认青春期启动并在小鼠和大鼠中进行生育力测定来确定生殖能力。
J Vis Exp. 2018 Oct 13(140):58352. doi: 10.3791/58352.
5
Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.国际循证指南关于多囊卵巢综合征评估和管理的推荐意见。
Fertil Steril. 2018 Aug;110(3):364-379. doi: 10.1016/j.fertnstert.2018.05.004. Epub 2018 Jul 19.
6
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood.孕期升高的抗苗勒氏管激素会重新编程胎儿，并导致成年后患多囊卵巢综合征。
Nat Med. 2018 Jun;24(6):834-846. doi: 10.1038/s41591-018-0035-5. Epub 2018 May 14.
7
Anogenital distance in newborn daughters of women with polycystic ovary syndrome indicates fetal testosterone exposure.患有多囊卵巢综合征的女性所生新生女婴的肛殖距表明胎儿期暴露于睾酮。
J Dev Orig Health Dis. 2018 Jun;9(3):307-314. doi: 10.1017/S2040174417001118. Epub 2018 Jan 9.
8
Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome.医生在多囊卵巢综合征的诊断标准和管理方面存在知识差距。
Fertil Steril. 2017 Jun;107(6):1380-1386.e1. doi: 10.1016/j.fertnstert.2017.04.011. Epub 2017 May 5.
9
Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome.神经内分泌雄激素作用是多囊卵巢综合征发生的关键卵巢外中介因素。
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3334-E3343. doi: 10.1073/pnas.1616467114. Epub 2017 Mar 20.
10
PCOS: Refining diagnostic features in PCOS to optimize health outcomes.多囊卵巢综合征：完善多囊卵巢综合征的诊断特征以优化健康结局。
Nat Rev Endocrinol. 2016 Nov;12(11):630-631. doi: 10.1038/nrendo.2016.157. Epub 2016 Sep 16.
Zotero 插件