多囊卵巢综合征：完善多囊卵巢综合征的诊断特征以优化健康结局。 - Suppr

PCOS: Refining diagnostic features in PCOS to optimize health outcomes.

作者信息

Boyle Jacqueline A, Teede Helena J

机构信息

Monash Centre of Health Research and Implementation, Monash University and Monash Health, Locked Bag 29, Clayton, Victoria 3168, Australia.

出版信息

Nat Rev Endocrinol. 2016 Nov;12(11):630-631. doi: 10.1038/nrendo.2016.157. Epub 2016 Sep 16.

DOI:10.1038/nrendo.2016.157

PMID:27636732

Abstract

摘要

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PCOS: Refining diagnostic features in PCOS to optimize health outcomes.多囊卵巢综合征：完善多囊卵巢综合征的诊断特征以优化健康结局。

Nat Rev Endocrinol. 2016 Nov;12(11):630-631. doi: 10.1038/nrendo.2016.157. Epub 2016 Sep 16.

Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome.多囊卵巢综合征女性的皮肤表现及全身相关情况。

JAMA Dermatol. 2016 Apr;152(4):391-8. doi: 10.1001/jamadermatol.2015.4498.

Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China.中国北方多囊卵巢综合征女性皮肤表现及代谢生物标志物的患病率

J Cosmet Dermatol. 2018 Jun;17(3):511-517. doi: 10.1111/jocd.12387. Epub 2017 Sep 21.

An update on the pathogenesis, inflammation, and metabolism in hirsutism and polycystic ovary syndrome.关于多毛症和多囊卵巢综合征的发病机制、炎症和代谢的最新研究进展。

Gynecol Endocrinol. 2010 Apr;26(4):281-96. doi: 10.3109/09513590903247873.

A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile.希腊莱斯博斯岛多囊卵巢综合征调查：激素与代谢特征

J Clin Endocrinol Metab. 1999 Nov;84(11):4006-11. doi: 10.1210/jcem.84.11.6148.

Spironolactone for hirsutism in polycystic ovary syndrome.

Ann Pharmacother. 2005 Sep;39(9):1517-21. doi: 10.1345/aph.1G025. Epub 2005 Aug 2.

Comparison of clinical and laboratory characteristics of cases with polycystic ovarian syndrome based on Rotterdam's criteria and women whose only clinical signs are oligo/anovulation or hirsutism.基于鹿特丹标准的多囊卵巢综合征病例与仅有少排卵/无排卵或多毛症等临床体征的女性的临床和实验室特征比较。

Arch Gynecol Obstet. 2006 Jul;274(4):227-32. doi: 10.1007/s00404-006-0173-8. Epub 2006 May 12.

Ovarian SAHA syndrome is associated with a more insulin-resistant profile and represents an independent risk factor for glucose abnormalities in women with polycystic ovary syndrome: a prospective controlled study.卵巢 SAHA 综合征与更具胰岛素抵抗特征相关，并且是多囊卵巢综合征女性葡萄糖异常的独立危险因素：一项前瞻性对照研究。

J Am Acad Dermatol. 2013 Dec;69(6):922-30. doi: 10.1016/j.jaad.2013.09.014. Epub 2013 Oct 11.

Hyperandrogenemia association with acne and hirsutism severity in Croatian women with polycystic ovary syndrome.克罗地亚多囊卵巢综合征女性中高雄激素血症与痤疮和多毛严重程度的关联。

Acta Dermatovenerol Croat. 2013;21(2):105-12.

The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.多囊卵巢综合征的患病率及表型特征：一项系统评价与荟萃分析

Hum Reprod. 2016 Dec;31(12):2841-2855. doi: 10.1093/humrep/dew218. Epub 2016 Sep 22.

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Androgens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome.雄激素驱动多囊卵巢综合征中依赖溶质载体家族1成员5（SLC1A5）的代谢重编程。

Nat Commun. 2025 Aug 15;16(1):7611. doi: 10.1038/s41467-025-62951-z.

Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome.多囊卵巢综合征中与糖酵解相关的生物标志物的鉴定与验证

Sci Rep. 2025 Jul 26;15(1):27199. doi: 10.1038/s41598-025-11591-w.

Single cell RNA sequencing reveals the role of local renin-angiotensin system in regulating ovarian physiological cycle and promoting PCOS.单细胞RNA测序揭示了局部肾素-血管紧张素系统在调节卵巢生理周期和促进多囊卵巢综合征中的作用。

Cell Death Discov. 2025 May 27;11(1):255. doi: 10.1038/s41420-025-02531-8.

Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.基于纳米氧化铈的纳米复合材料调节免疫微环境治疗多囊卵巢综合征。

J Nanobiotechnology. 2023 Nov 7;21(1):412. doi: 10.1186/s12951-023-02182-w.

Updates on Molecular Targets and Epigenetic-Based Therapies for PCOS.多囊卵巢综合征分子靶点及基于表观遗传学的治疗进展

Reprod Sci. 2023 Mar;30(3):772-786. doi: 10.1007/s43032-022-01013-x. Epub 2022 Jun 28.

Rodent models in placental research. Implications for fetal origins of adult disease.胎盘研究中的啮齿动物模型。对成人疾病胎儿起源的影响。

Anim Reprod. 2022 Apr 22;19(1):e20210134. doi: 10.1590/1984-3143-AR2021-0134. eCollection 2022.

Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS.高雄激素血症和排卵功能障碍的临床表现与克什米尔多囊卵巢综合征女性胰岛素受体基因酪氨酸激酶结构域His1058 C/T单核苷酸多态性（rs1799817）无关。

Int J Endocrinol. 2021 Dec 6;2021:7522487. doi: 10.1155/2021/7522487. eCollection 2021.

Polycystic ovary syndrome mouse model by prenatal exposure to high anti-Müllerian hormone.产前暴露于高抗苗勒管激素建立多囊卵巢综合征小鼠模型

STAR Protoc. 2021 Jul 31;2(3):100684. doi: 10.1016/j.xpro.2021.100684. eCollection 2021 Sep 17.

Gut and vaginal microbiomes on steroids: implications for women's health.肠道和阴道微生物组的类固醇影响：对女性健康的影响。

Trends Endocrinol Metab. 2021 Aug;32(8):554-565. doi: 10.1016/j.tem.2021.04.014. Epub 2021 May 25.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.基于肠促胰岛素的疗法在多囊卵巢综合征中的潜在作用：当前证据的叙述性综述

Ther Adv Endocrinol Metab. 2021 Jan 27;12:2042018821989238. doi: 10.1177/2042018821989238. eCollection 2021.

本文引用的文献

Raising threshold for diagnosis of polycystic ovary syndrome excludes population of patients with metabolic risk.多囊卵巢综合征诊断阈值的提高将排除具有代谢风险的患者人群。

Fertil Steril. 2016 Oct;106(5):1244-1251. doi: 10.1016/j.fertnstert.2016.06.026. Epub 2016 Jul 18.

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.多囊卵巢综合征的全基因组关联研究表明，欧洲血统人群的促性腺激素分泌存在改变。

Nat Commun. 2015 Aug 18;6:7502. doi: 10.1038/ncomms8502.

Women's experiences of polycystic ovary syndrome diagnosis.多囊卵巢综合征诊断中女性的经历。

Fam Pract. 2014 Oct;31(5):545-9. doi: 10.1093/fampra/cmu028. Epub 2014 Jun 12.

Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society.多囊卵巢形态的定义和意义：雄激素过多和多囊卵巢综合征学会的一份工作组报告。

Hum Reprod Update. 2014 May-Jun;20(3):334-52. doi: 10.1093/humupd/dmt061. Epub 2013 Dec 16.

Longitudinal weight gain in women identified with polycystic ovary syndrome: results of an observational study in young women.多囊卵巢综合征女性的纵向体重增加：一项对年轻女性的观察性研究结果。

Obesity (Silver Spring). 2013 Aug;21(8):1526-32. doi: 10.1002/oby.20213. Epub 2013 Jul 2.

Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp.多囊卵巢综合征女性在正常血糖高胰岛素钳夹试验中存在固有胰岛素抵抗。

Hum Reprod. 2013 Mar;28(3):777-84. doi: 10.1093/humrep/des463. Epub 2013 Jan 12.

Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline.多囊卵巢综合征的评估与管理：循证指南概要

Med J Aust. 2011 Sep 19;195(6):S65-112. doi: 10.5694/mja11.10915.

A very large proportion of young Danish women have polycystic ovaries: is a revision of the Rotterdam criteria needed?很大一部分丹麦年轻女性患有多囊卵巢：是否需要修订 Rotterdam 标准？

Hum Reprod. 2010 Dec;25(12):3117-22. doi: 10.1093/humrep/deq273. Epub 2010 Oct 11.

The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria.在对比不同诊断标准的情况下，对社区样本中多囊卵巢综合征的流行情况进行评估。

Hum Reprod. 2010 Feb;25(2):544-51. doi: 10.1093/humrep/dep399. Epub 2009 Nov 12.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.2003年修订的关于多囊卵巢综合征诊断标准及长期健康风险的共识。

Fertil Steril. 2004 Jan;81(1):19-25. doi: 10.1016/j.fertnstert.2003.10.004.

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