Reiman H M, Goellner J R, Woods J E, Mixter R C
Department of Pathology, Mayo Clinic, Rochester, MN 55905.
Cancer. 1987 Nov 1;60(9):2269-74. doi: 10.1002/1097-0142(19871101)60:9<2269::aid-cncr2820600928>3.0.co;2-w.
The pathologic and clinical findings in cases of desmoplastic melanoma of the head and neck seen at the Mayo Clinic in Rochester, Minnesota, during the past 20 years were analyzed. The nine cases acceptable for study included six usual and three neurotropic variants as defined by light microscopic criteria. Immunopathologic studies of all cases using S-100 protein and desmin, and electron microscopy in four cases, were unsuccessful in distinguishing between the two subtypes. Clinical behavior was aggressive regardless of histologic subtype. Extensive surgical treatment when the diagnosis is made is advocated. The combination of the rarity and the subtle histologic features of desmoplastic melanoma continues to make the correct diagnosis of this entity a challenge for the clinician and pathologist.
对过去20年在明尼苏达州罗切斯特市梅奥诊所所见的头颈部促纤维增生性黑色素瘤病例的病理和临床发现进行了分析。根据光镜标准，9例可接受研究的病例包括6例常见型和3例亲神经性变型。所有病例均采用S-100蛋白和结蛋白进行免疫病理研究，4例进行了电子显微镜检查，但均未能区分这两种亚型。无论组织学亚型如何，临床行为均具有侵袭性。提倡在做出诊断时进行广泛的手术治疗。促纤维增生性黑色素瘤的罕见性及其细微的组织学特征，仍然使临床医生和病理学家对该实体的正确诊断面临挑战。
