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显示平滑肌分化的恶性黑色素瘤。

Malignant melanoma showing smooth muscle differentiation.

作者信息

Banerjee S S, Bishop P W, Nicholson C M, Eyden B P

机构信息

Department of Pathology, Christie Hospital, Manchester.

出版信息

J Clin Pathol. 1996 Nov;49(11):950-1. doi: 10.1136/jcp.49.11.950.

DOI:10.1136/jcp.49.11.950
PMID:8944620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500840/
Abstract

A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.

摘要

描述了一例独特的病例，一名54岁女性的腋窝淋巴结转移性非促纤维增生性肉瘤样恶性黑色素瘤显示平滑肌分化。肿瘤细胞表现出α-平滑肌肌动蛋白、HHF-35和结蛋白阳性，但S100蛋白和HMB-45阴性。超微结构检查显示为平滑肌表型，且没有肌成纤维细胞分化的证据，这是促纤维增生性黑色素瘤中先前描述的特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/452d/500840/74fd7564fbdf/jclinpath00248-0087-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/452d/500840/93ef5c31b7f7/jclinpath00248-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/452d/500840/74fd7564fbdf/jclinpath00248-0087-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/452d/500840/93ef5c31b7f7/jclinpath00248-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/452d/500840/74fd7564fbdf/jclinpath00248-0087-b.jpg

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本文引用的文献

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An immunophenotypic survey of malignant melanomas.恶性黑色素瘤的免疫表型研究
Histopathology. 1993 Aug;23(2):159-66. doi: 10.1111/j.1365-2559.1993.tb00474.x.
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Case Rep Dermatol. 2014 Jan 24;6(1):16-9. doi: 10.1159/000358375. eCollection 2014 Jan.
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Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.转移性黑色素瘤具有显著的腺癌分化，说明黑色素瘤的表型可塑性。
Am J Surg Pathol. 2011 Sep;35(9):1413-8. doi: 10.1097/PAS.0b013e31822280d8.
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Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases.促纤维增生性嗜神经性黑色素瘤。28例临床病理分析。
Cancer. 1995 Jan 15;75(2):478-94. doi: 10.1002/1097-0142(19950115)75:2<478::aid-cncr2820750211>3.0.co;2-o.
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Cancer. 1987 Nov 1;60(9):2269-74. doi: 10.1002/1097-0142(19871101)60:9<2269::aid-cncr2820600928>3.0.co;2-w.
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