miRNA-146a基因多态性Rs2910164与白塞病的关联：一项荟萃分析。
Association of miRNA-146a Gene Polymorphism Rs2910164 with Behcet's Disease: A Meta-analysis.
作者信息
Shan Jiankang, Zhou Pengyi, Liu Zhenzhen, Zheng Kaifeng, Jin Xuemin, Du Liping
机构信息
The Academy of Medical Sciences, Zhengzhou University, Zhengzhou, P.R. China.
Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, P.R. China.
出版信息
Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1883-1889. doi: 10.1080/09273948.2021.1968002. Epub 2021 Aug 17.
BACKGROUND
A meta-analysis was performed by summarizing relevant researches to evaluate the relationship between miRNA-146a gene polymorphism rs2910164 and Behcet's disease (BD).
METHODS
A systematic search of published studies was conducted in PubMed and Embase. Five eligible studies involving 1167 BD cases and 1662 controls were included in the current meta-analysis.
RESULTS
The results suggested that the polymorphism rs2910164 was correlated with BD susceptibility in all genetic models. In subgroup analysis according to ethnicity, the relationship between this polymorphism and BD was more significant in Caucasians (allele model: OR = 0.49, 95% CI 0.39-0.61; heterozygote model: OR = 0.35, 95% CI 0.26-0.47; homozygote model: OR = 0.29, 95% CI 0.16-0.53; dominant model: OR = 0.34, 95% CI 0.25-0.45; recessive model: OR = 0.56, 95% CI 0.50-0.72) than that in Asians.
CONCLUSION
In conclusion, this meta-analysis indicates that miRNA-146a gene polymorphism rs2910164 G allele confers BD susceptibility, especially in Caucasians.
背景
通过总结相关研究进行荟萃分析，以评估miRNA - 146a基因多态性rs2910164与白塞病（BD）之间的关系。
方法
在PubMed和Embase中对已发表的研究进行系统检索。本荟萃分析纳入了五项符合条件的研究，涉及1167例BD病例和1662例对照。
结果
结果表明，在所有遗传模型中，多态性rs2910164与BD易感性相关。在按种族进行的亚组分析中，该多态性与BD之间的关系在白种人中比在亚洲人中更显著（等位基因模型：OR = 0.49，95%CI 0.39 - 0.61；杂合子模型：OR = 0.35，95%CI 0.26 - 0.47；纯合子模型：OR = 0.29，95%CI 0.16 - 0.53；显性模型：OR = 0.34，95%CI 0.25 - 0.45；隐性模型：OR = 0.56，95%CI 0.50 - 0.72）。
结论
总之，本荟萃分析表明，miRNA - 146a基因多态性rs2910164的G等位基因赋予BD易感性，尤其是在白种人中。
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