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皂甙通过调节小胶质细胞极化和自噬来减轻衰老大鼠的认知障碍。

Saponins from attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy.

机构信息

Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, China.

Department of Pharmacy, College of Medicine, Wuhan University of Science and Technology, Wuhan, China.

出版信息

Pharm Biol. 2021 Dec;59(1):1117-1125. doi: 10.1080/13880209.2021.1961824.

DOI:10.1080/13880209.2021.1961824
PMID:34403300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8381902/
Abstract

CONTEXT

is the dried rhizome of C.A. Mey. (Araliaceae). Saponins from (SPJ) exhibit anti-inflammatory and antioxidative effects.

OBJECTIVE

To explore the neuroprotective effect of SPJ on natural ageing of rat.

MATERIALS AND METHODS

Sprague-Dawley (SD) rats 18-month-old were divided into ageing control, ageing treated with SPJ 10 or 30 mg/kg ( = 8). Five-month-old rats were taken as the adult control ( = 8). Rats were fed regular feed or feed containing SPJ for 4 months. Cognitive level was evaluated by Morris water maze (MWM) test. The mechanisms of SPJ's neuroprotection were evaluated by transmission electron microscope, western blot analysis, and immunofluorescence and .

RESULTS

SPJ attenuated ageing-induced cognitive impairment as indicated by elevated number of times crossing the target platform (from 1.63 to 3.5) and longer time spent in the target platform quadrant (from 1.33 to 1.98). Meanwhile, SPJ improved the morphology of microglia and synapse, and activated M2 microglia polarisation including increased hippocampus levels of CD206 (from 0.98 to 1.47) and YM-1 (from 0.67 to 1.1), and enhanced autophagy-related proteins LC3B (from 0.48 to 0.82), Beclin1 (from 0.32 to 0.51), Atg5 (from 0.22 to 0.89) whereas decreased p62 level (from 0.71 to 0.45) of ageing rats. study also showed that SPJ regulated the microglial polarisation and autophagy.

DISCUSSION AND CONCLUSIONS

SPJ improved cognitive deficits of ageing rats through attenuating microglial inflammation and enhancing microglial autophagy, which could be used to treat neurodegenerative disorders.

摘要

背景

是 C.A. Mey.（伞形科）的干根茎。 来自 （SPJ）的皂苷具有抗炎和抗氧化作用。

目的

探讨 SPJ 对大鼠自然衰老的神经保护作用。

材料和方法

将 18 月龄的 Sprague-Dawley（SD）大鼠分为衰老对照组、衰老 SPJ 10 或 30mg/kg 治疗组（n=8）。将 5 月龄大鼠作为成年对照组（n=8）。大鼠分别给予常规饲料或含 SPJ 的饲料喂养 4 个月。通过 Morris 水迷宫（MWM）测试评估认知水平。通过透射电镜、Western blot 分析、免疫荧光和免疫组化评估 SPJ 的神经保护机制。

结果

SPJ 可减轻衰老引起的认知障碍，表现为穿越目标平台的次数增加（从 1.63 次增加到 3.5 次）和在目标平台象限停留的时间延长（从 1.33 秒增加到 1.98 秒）。同时，SPJ 改善了小胶质细胞和突触的形态，激活了 M2 小胶质细胞极化，包括增加海马 CD206（从 0.98 增加到 1.47）和 YM-1（从 0.67 增加到 1.1）水平，增强自噬相关蛋白 LC3B（从 0.48 增加到 0.82）、Beclin1（从 0.32 增加到 0.51）、Atg5（从 0.22 增加到 0.89），同时降低衰老大鼠 p62 水平（从 0.71 降低到 0.45）。 研究还表明，SPJ 调节了小胶质细胞的极化和自噬。

讨论和结论

SPJ 通过减轻小胶质细胞炎症和增强小胶质细胞自噬改善衰老大鼠的认知缺陷，可用于治疗神经退行性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/d9293afad035/IPHB_A_1961824_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/d53e6a3eaa2e/IPHB_A_1961824_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/a5abeb24c058/IPHB_A_1961824_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/b94986a7d503/IPHB_A_1961824_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/5b23dcc5e861/IPHB_A_1961824_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/910c543325df/IPHB_A_1961824_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/d9293afad035/IPHB_A_1961824_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/d53e6a3eaa2e/IPHB_A_1961824_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/a5abeb24c058/IPHB_A_1961824_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/b94986a7d503/IPHB_A_1961824_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/5b23dcc5e861/IPHB_A_1961824_F0004_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/910c543325df/IPHB_A_1961824_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd3b/8381902/d9293afad035/IPHB_A_1961824_F0006_B.jpg

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