Family Health Department, Health Deputy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Midwifery, Marand Branch, Islamic Azad University, Marand, Iran.
BMC Pregnancy Childbirth. 2021 Aug 17;21(1):563. doi: 10.1186/s12884-021-04010-1.
To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor.
The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3.
Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (- 1.37, - 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects.
Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects.
评估地塞米松给药对引产开始至活跃期的间隔时间的影响。
检索了 PubMed、Cochrane Library、Embase、Scopus 和 Web of Science 数据库，截至 2021 年 6 月 27 日，检索了发表的研究。纳入了两种类型的文章：a）全文发表在英语或任何其他语言的文章，b）随机对照试验（RCTs）。参与者为足月或过期妊娠的初产妇或多产妇。干预组接受了地塞米松的静脉或羊膜外给药，而对照组在开始引产之前接受了生理盐水或未治疗。所有数据均使用 Review Manager 5.3 进行分析。
纳入了 17 项研究，共 1879 名患者。地塞米松给药可将引产开始至活跃期开始的间隔时间缩短约 70 分钟[MD：-1.17（-1.37，-1.00）；P<0.00001]。地塞米松组第一产程的持续时间比对照组短约 88 分钟。没有母体和胎儿的不良反应。
地塞米松可显著缩短引产至活跃期的间隔时间和第一产程的时间，且对母体和胎儿无不良反应。
