Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Pin 160012, India.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Pin 160012, India.
Trials. 2021 Aug 17;22(1):540. doi: 10.1186/s13063-021-05490-4.
To compare the efficacy of chlorhexidine-alcohol and povidone-iodine as preoperative antiseptic skin preparation for prevention of surgical site infection (SSI) after cesarean delivery (CD).
A total of 311 eligible women who underwent CS were recruited in the study after fulfilling all the eligibility and exclusion criteria. Patients were randomized into two groups (153 in chlorhexidine-alcohol group and 158 in povidone-iodine group) by a computer-generated randomization table. Patients were followed for a period of 30 days in postoperative period to monitor for SSI.
The rate of SSI in the chlorhexidine-alcohol group is 5.4% and that of the povidone-iodine group is 8.6%. E. coli, K. pneumoniae, and Acinetobacter baumannii were the most common organisms isolated. E. coli was found in 9.5% of the total SSI cases.
The study found that the patients who received chlorhexidine-alcohol as skin antiseptic had less chance of developing SSI than those who received povidone-iodine; however, it did not reach a statistical significance.
Clinical Trials Registry of India CTRI/2018/05/014294 . Registered on May 31, 2018.
比较洗必泰酒精和聚维酮碘作为剖宫产术（CD）前皮肤消毒预防手术部位感染（SSI）的效果。
本研究共纳入了 311 名符合条件的 CD 患者，他们均符合所有纳入和排除标准。患者通过计算机生成的随机数表被随机分为两组（洗必泰酒精组 153 例，聚维酮碘组 158 例）。对患者进行为期 30 天的术后随访，以监测 SSI 发生情况。
洗必泰酒精组的 SSI 发生率为 5.4%，聚维酮碘组的 SSI 发生率为 8.6%。最常见的分离菌为大肠埃希菌、肺炎克雷伯菌和鲍曼不动杆菌。在所有 SSI 病例中，大肠埃希菌的检出率为 9.5%。
本研究发现，接受洗必泰酒精皮肤消毒的患者发生 SSI 的几率低于接受聚维酮碘皮肤消毒的患者，但差异无统计学意义。
印度临床试验注册中心 CTRI/2018/05/014294 。注册于 2018 年 5 月 31 日。
