Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Clin Radiol. 2021 Nov;76(11):863.e1-863.e10. doi: 10.1016/j.crad.2021.07.011. Epub 2021 Aug 14.
To objectively examine the agreement and correlation between four-dimensional (4D) flow magnetic resonance imaging (MRI) and traditional two-dimensional (2D) phase-contrast (PC) MRI with the reference standard of Doppler echocardiography for measuring peak blood velocity at the cardiac valve and great arteries, and to assess if 4D flow MRI offers an advantage over the traditional 2D method.
The literature was searched systematically for studies that evaluate the degree of correlation and agreement between 4D flow MRI or 2D PC MRI and Doppler retrieved from PubMed, EMBASE, and the Cochrane Library. A meta-analysis was conducted to determine the peak velocity pooled bias with 95% limits of agreement (LoA) and correlation coefficient (r) for 4D flow MRI and 2D PC MRI compared with Doppler.
Ten studies that compared 4D flow MRI with Doppler and 12 studies that compared 2D PC MRI with Doppler were included. 4D flow MRI showed an underestimation with bias and 95% LoA of -0.09 (-0.41, 0.24) m/s (p=0.079) while 2D PC MRI showed a poorer agreement with a bias and 95% LoA of -0.25 (-0.53, 0.03), p=0.596. 4D flow MRI and 2D PC MRI showed a strong correlation with R=0.80 (95% CI 0.75, 0.84; p<0.001) and R=0.83 (95% CI 0.79, 0.87; p<0.001), respectively.
In this meta-analysis, 4D flow MRI provides improved assessment of peak velocity when compared with traditional 2D PC MRI. 4D flow MRI can be considered an important complement or substitute to Doppler echocardiography for peak velocity assessment.
客观地比较四维（4D）血流磁共振成像（MRI）与传统二维（2D）相位对比（PC）MRI 与多普勒超声心动图的参考标准在测量心瓣膜和大动脉峰值血流速度方面的一致性和相关性，并评估 4D 流 MRI 是否优于传统 2D 方法。
系统地从 PubMed、EMBASE 和 Cochrane 图书馆中检索评估 4D 流 MRI 或 2D PC MRI 与多普勒之间相关性和一致性的文献。进行荟萃分析以确定与多普勒相比，4D 流 MRI 和 2D PC MRI 的峰值速度汇总偏差、95%一致性区间（LoA）和相关系数（r）。
纳入了 10 项比较 4D 流 MRI 与多普勒的研究和 12 项比较 2D PC MRI 与多普勒的研究。4D 流 MRI 显示低估，偏差和 95%LoA 为-0.09（-0.41，0.24）m/s（p=0.079），而 2D PC MRI 显示一致性较差，偏差和 95%LoA 为-0.25（-0.53，0.03），p=0.596。4D 流 MRI 和 2D PC MRI 显示出很强的相关性，R=0.80（95%CI 0.75，0.84；p<0.001）和 R=0.83（95%CI 0.79，0.87；p<0.001）。
在这项荟萃分析中，4D 流 MRI 在评估峰值速度方面优于传统的 2D PC MRI。4D 流 MRI 可以被认为是评估峰值速度的重要补充或替代多普勒超声心动图。
