Delmée M, Vandercam B, Avesani V, Michaux J L
Microbiology Department, Catholic University of Louvain, Brussels, Belgium.
Eur J Clin Microbiol. 1987 Dec;6(6):623-7. doi: 10.1007/BF02013056.
A 29-month prospective study was carried out in a leukemia unit with the aim of investigating the epidemiology of Clostridium difficile infections and limiting their spread. Systematic cultures of stools and assays for cytotoxin were performed on patient admission and at weekly intervals, yielding 1,355 cultures and assays. The study period was divided in period A, before total unit renovation, and period B, afterwards. During period B all patient carriers of Clostridium difficile received vancomycin. A comparison of the two periods showed that the percentage of positive cultures fell from 16.6% to 3.6% and the positive toxin assays from 9.9% to 1.2%. It was concluded that colonization by Clostridium difficile can be prevented in hospital wards with generally high rates of infection by a combination of decontamination of the environment, introduction of preventive measures and treatment of Clostridium difficile carriage with vancomycin.
在一个白血病治疗单元进行了一项为期29个月的前瞻性研究，旨在调查艰难梭菌感染的流行病学情况并限制其传播。在患者入院时及每周进行一次粪便系统培养和细胞毒素检测，共获得1355次培养和检测结果。研究期分为A期（病房全面翻新前）和B期（翻新后）。在B期，所有艰难梭菌患者携带者均接受了万古霉素治疗。两个时期的比较显示，培养阳性率从16.6%降至3.6%，毒素检测阳性率从9.9%降至1.2%。得出的结论是，在感染率普遍较高的医院病房中，通过环境去污、采取预防措施以及用万古霉素治疗艰难梭菌携带情况相结合的方法，可以预防艰难梭菌的定植。
