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从艾滋病患者和人类免疫缺陷病毒阴性患者中分离出的艰难梭菌菌株的肠毒素产生、细胞毒素产生、血清分型及抗菌药物敏感性比较。

Comparison of enterotoxin production, cytotoxin production, serogrouping, and antimicrobial susceptibilities of Clostridium difficile strains isolated from AIDS and human immunodeficiency virus-negative patients.

作者信息

Barbut F, Depitre C, Delmée M, Corthier G, Petit J C

机构信息

Department of Microbiology, Saint-Antoine Hospital, Paris 12, France.

出版信息

J Clin Microbiol. 1993 Mar;31(3):740-2. doi: 10.1128/jcm.31.3.740-742.1993.

DOI:10.1128/jcm.31.3.740-742.1993
PMID:8458977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262860/
Abstract

We analyzed and compared Clostridium difficile strains isolated from diarrheic stools of 49 human immunodeficiency virus (HIV)-negative and 50 AIDS patients. Our results suggest that distribution patterns of serogroups are different in these two populations. Serogroup C (which has been previously reported to be very resistant to antimicrobial agents) represents 66.0 and 18.4% of the isolates from AIDS and HIV-negative patients, respectively (P < 0.001); the selection of serogroup C could be explained by multiple antibiotic pressure to which AIDS patients have been subjected.

摘要

我们分析并比较了从49名人类免疫缺陷病毒（HIV）阴性和50名艾滋病患者腹泻粪便中分离出的艰难梭菌菌株。我们的结果表明，这两个人群中血清型的分布模式不同。血清型C（此前报道对抗菌药物具有很强的抗性）分别占艾滋病患者和HIV阴性患者分离株的66.0%和18.4%（P < 0.001）；血清型C的选择可以用艾滋病患者所承受的多种抗生素压力来解释。

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Comparison of enterotoxin production, cytotoxin production, serogrouping, and antimicrobial susceptibilities of Clostridium difficile strains isolated from AIDS and human immunodeficiency virus-negative patients.从艾滋病患者和人类免疫缺陷病毒阴性患者中分离出的艰难梭菌菌株的肠毒素产生、细胞毒素产生、血清分型及抗菌药物敏感性比较。
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本文引用的文献

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Serogrouping of Clostridium difficile strains by slide agglutination.通过玻片凝集法对艰难梭菌菌株进行血清分型。
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The epidemiology of Clostridium difficile with use of a typing scheme: nosocomial acquisition and cross-infection among immunocompromised patients.艰难梭菌的流行病学研究及分型方案：免疫功能低下患者的医院内获得与交叉感染
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Clostridium difficile: its disease and toxins.艰难梭菌：其所致疾病与毒素
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Correlation between serogroup and susceptibility to chloramphenicol, clindamycin, erythromycin, rifampicin and tetracycline among 308 isolates of Clostridium difficile.308株艰难梭菌分离株中血清型与对氯霉素、克林霉素、红霉素、利福平及四环素敏感性之间的相关性
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Nosocomial acquisition of Clostridium difficile infection.医院获得性艰难梭菌感染。
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Serotyping of Clostridium difficile.艰难梭菌的血清分型
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Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A.通过使用抗艰难梭菌毒素A单克隆抗体对悉生小鼠实验性假膜性结肠炎的保护作用。
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Epidemiologic markers of Clostridium difficile.艰难梭菌的流行病学标志物
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