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本文引用的文献

1
Dynamics of swollen gel layers anchored to solid surfaces.附着于固体表面的肿胀凝胶层的动力学
Soft Matter. 2008 Jun 20;4(7):1443-1447. doi: 10.1039/b801468j.
2
Antimicrobial and cell-compatible surface-attached polymer networks - how the correlation of chemical structure to physical and biological data leads to a modified mechanism of action.抗菌且细胞兼容的表面附着聚合物网络——化学结构与物理和生物学数据的相关性如何导致作用机制的改变。
J Mater Chem B. 2015 Aug 14;3(30):6224-6238. doi: 10.1039/c5tb00906e. Epub 2015 Jul 2.
3
On the Limits of Benzophenone as Cross-Linker for Surface-Attached Polymer Hydrogels.关于二苯甲酮作为表面附着聚合物水凝胶交联剂的局限性
Polymers (Basel). 2017 Dec 7;9(12):686. doi: 10.3390/polym9120686.
4
Surface-attached hydrogel coatings via C,H-insertion crosslinking for biomedical and bioanalytical applications (Review).用于生物医学和生物分析应用的通过C-H插入交联的表面附着水凝胶涂层（综述）
Biointerphases. 2017 Dec 8;13(1):010801. doi: 10.1116/1.4999786.
5
Increased Hydrophobic Block Length of PTDMs Promotes Protein Internalization.PTDM疏水性嵌段长度增加促进蛋白质内化。
Polym Chem. 2016 Dec 28;7(48):7514-7521. doi: 10.1039/C6PY01615D. Epub 2016 Nov 14.
6
Malonic Acid Diazoesters for C-H Insertion Crosslinking (CHic) Reactions: A Versatile Method for the Generation of Tailor-Made Surfaces.丙二酸重氮酯用于 C-H 插入交联 (CHic) 反应：一种用于生成定制表面的通用方法。
Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14405-14410. doi: 10.1002/anie.201704486. Epub 2017 Oct 11.
7
Sequence segregation improves non-covalent protein delivery.序列隔离可提高非共价蛋白递呈。
J Control Release. 2017 May 28;254:131-136. doi: 10.1016/j.jconrel.2017.03.387. Epub 2017 Mar 29.
8
A Simultaneously Antimicrobial, Protein-Repellent, and Cell-Compatible Polyzwitterion Network.一种同时具有抗菌、抗蛋白和细胞相容性的聚两性离子网络。
Biomacromolecules. 2017 Apr 10;18(4):1373-1386. doi: 10.1021/acs.biomac.7b00100. Epub 2017 Mar 24.
9
Biophysical characterization of quaternary pyridinium functionalized polynorbornenes for DNA complexation and their cellular interactions.用于DNA复合的季铵化吡啶鎓官能化聚降冰片烯的生物物理特性及其细胞相互作用
Biopolymers. 2017 Apr;107(4). doi: 10.1002/bip.23005.
10
Towards Self-regenerating Antimicrobial Polymer Surfaces.迈向自我再生抗菌聚合物表面
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通过C，H插入交联（CHic）制备的非分层聚合物水凝胶涂层——聚（氧杂降冰片烯）的案例研究

Non-delaminating Polymer Hydrogel Coatings via C,H-Insertion Crosslinking (CHic) - A Case Study of Poly(oxanorbornenes).

作者信息

Riga Esther K, Rühe Jürgen, Lienkamp Karen

机构信息

Department of Microsystems Engineering (IMTEK) and Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), Albert-Ludwigs-Universität, Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany.

出版信息

Macromol Chem Phys. 2018 Oct 16;219(23). doi: 10.1002/macp.201800397. eCollection 2018 Dec 5.

DOI:10.1002/macp.201800397
PMID:34404979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7611512/
Abstract

Robust, non-delaminating polymer coatings and hydrogels are needed for technical and biomedical applications. This study focusses on surface-attached poly(oxanorbornene) hydrogels obtained by simultaneous UV-activated crosslinking and surface-immobilization. The synthesis and copolymerization of two oxanorbornene monomers carrying the UV-crosslinkers malonic acid diazoester or benzophenone, which can both undergo UV-triggered C,H-insertion crosslinking (CHic), is presented. The crosslinking efficiency and network stability of hydrogels made from these self-crosslinkable polymers are studied and compared to the properties of poly(oxanorbornene) networks obtained by UV-triggered thiol-ene-reactions involving a low molecular weight crosslinker. Smooth, defect-free, non-delaminating hydrogel coatings were obtained by CHic, not only on laboratory model surfaces but also on a technical product.

摘要

技术和生物医学应用需要坚固、不分层的聚合物涂层和水凝胶。本研究聚焦于通过紫外线激活交联和表面固定化获得的表面附着聚（氧化降冰片烯）水凝胶。本文介绍了两种带有紫外线交联剂丙二酸重氮酯或二苯甲酮的氧化降冰片烯单体的合成与共聚，这两种交联剂均可进行紫外线引发的C-H插入交联（CHic）。研究了由这些可自交联聚合物制成的水凝胶的交联效率和网络稳定性，并与通过涉及低分子量交联剂的紫外线引发硫醇-烯反应获得的聚（氧化降冰片烯）网络的性能进行了比较。通过CHic获得了光滑、无缺陷、不分层的水凝胶涂层，不仅在实验室模型表面，而且在技术产品上也获得了这种涂层。