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14例脑膜血管梅毒新病例分析：对一个老问题的重新关注。

Analysis of Fourteen New Cases of Meningovascular Syphilis: Renewed Interest in an Old Problem.

作者信息

Aziouaz Faiza, Mabrouki Fatima Zahra, Chraa Mohammed, Louhab Nisrine, Adali Nawal, Hajjaj Imane, Kissani Najib, Mebrouk Yassine

机构信息

Neurology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Oujda, MAR.

Ophthalmology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Oujda, MAR.

出版信息

Cureus. 2021 Aug 6;13(8):e16951. doi: 10.7759/cureus.16951. eCollection 2021 Aug.

DOI:10.7759/cureus.16951
PMID:34405075
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8354207/
Abstract

Neurosyphilis (NS) remains a public health problem. Several recent reports suggest a worldwide increase in the incidence of this condition. Various syndromes can occur in NS, such as syphilitic meningitis, meningovascular syphilis, parenchymatous and gummatous neurosyphilis. Syphilis meningovascular will be the focus of this study. We report 14 new observations of meningovascular syphilis. A review of demographic and clinical features, neuroimaging findings, cerebrospinal fluid changes, treatment and outcome, pathophysiology mechanism of meningovascular syphilis are presented.

摘要

神经梅毒（NS）仍然是一个公共卫生问题。最近的几份报告表明，这种疾病在全球范围内的发病率有所上升。神经梅毒可出现多种综合征，如梅毒性脑膜炎、脑膜血管梅毒、实质性和树胶肿性神经梅毒。脑膜血管梅毒将是本研究的重点。我们报告了14例脑膜血管梅毒的新病例。本文对脑膜血管梅毒的人口统计学和临床特征、神经影像学表现、脑脊液变化、治疗及预后、病理生理机制进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/7bb00854f445/cureus-0013-00000016951-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/e2890e02bed7/cureus-0013-00000016951-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/8229147f48f8/cureus-0013-00000016951-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/7bb00854f445/cureus-0013-00000016951-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/e2890e02bed7/cureus-0013-00000016951-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/8229147f48f8/cureus-0013-00000016951-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e68e/8354207/7bb00854f445/cureus-0013-00000016951-i03.jpg

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本文引用的文献

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[Neurosyphilis in the patients with and without HIV infection: description and comparison of two historical cohorts].[合并及未合并HIV感染患者的神经梅毒：两个历史队列的描述与比较]
Rev Chilena Infectol. 2009 Dec;26(6):540-7. Epub 2009 Dec 21.
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Neurosyphilis in the age of AIDS: clinical and laboratory features.艾滋病时代的神经梅毒：临床和实验室特征。
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[Stroke, HIV and meningovascular syphilis: study of three cases].[中风、艾滋病毒与脑膜血管梅毒：三例病例研究]
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Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests.非梅毒螺旋体试验在神经梅毒诊断中的应用：性病研究实验室（VDRL）试验和快速血浆反应素环状卡片试验（RPR）评估
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Effect of HIV infection on the course of syphilis.艾滋病毒感染对梅毒病程的影响。
AIDS Rev. 2008 Apr-Jun;10(2):85-92.
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[Meningovascular syphilis: study of five cases].[脑膜血管梅毒：5例病例研究]
Rev Neurol (Paris). 2008 Apr;164(4):369-73. doi: 10.1016/j.neurol.2007.12.007. Epub 2008 Apr 1.
8
CT and MR findings in HIV-negative neurosyphilis.HIV阴性神经梅毒的CT和MR表现
Eur J Radiol. 2008 Apr;66(1):1-6. doi: 10.1016/j.ejrad.2007.05.018. Epub 2007 Jul 12.
9
Current controversies in the management of adult syphilis.成人梅毒治疗中的当前争议
Clin Infect Dis. 2007 Apr 1;44 Suppl 3:S130-46. doi: 10.1086/511426.
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Epilepsia. 2007 Feb;48(2):390-3. doi: 10.1111/j.1528-1167.2007.00921.x.