RNA 修饰如何调节抗病毒反应。
How RNA modifications regulate the antiviral response.
机构信息
Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC, USA.
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
出版信息
Immunol Rev. 2021 Nov;304(1):169-180. doi: 10.1111/imr.13020. Epub 2021 Aug 17.
Abstract
Induction of the antiviral innate immune response is highly regulated at the RNA level, particularly by RNA modifications. Recent discoveries have revealed how RNA modifications play key roles in cellular surveillance of nucleic acids and in controlling gene expression in response to viral infection. These modifications have emerged as being essential for a functional antiviral response and maintaining cellular homeostasis. In this review, we will highlight these and other discoveries that describe how the antiviral response is controlled by modifications to both viral and cellular RNA, focusing on how mRNA cap modifications, N6-methyladenosine, and RNA editing all contribute to coordinating an efficient response that properly controls viral infection.
摘要
抗病毒先天免疫反应的诱导在 RNA 水平受到高度调控，特别是通过 RNA 修饰。最近的发现揭示了 RNA 修饰如何在细胞对核酸的监测以及在响应病毒感染控制基因表达中发挥关键作用。这些修饰已成为功能性抗病毒反应和维持细胞内稳态所必需的。在这篇综述中，我们将强调这些以及其他描述抗病毒反应如何受病毒和细胞 RNA 修饰控制的发现，重点介绍 mRNA 帽修饰、N6-甲基腺苷和 RNA 编辑如何共同协调有效的反应，从而正确控制病毒感染。
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