Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Curr Opin Genet Dev. 2024 Aug;87:102213. doi: 10.1016/j.gde.2024.102213. Epub 2024 Jun 19.
The RNA modification of N-methyladenosine (mA) controls many aspects of RNA function that impact biological processes, including viral infection. In this review, we highlight recent work that shapes our current understanding of the diverse mechanisms by which mA can regulate viral infection by acting on viral or cellular mRNA molecules. We focus on emerging concepts and understanding, including how viral infection alters the localization and function of mA machinery proteins, how mA regulates antiviral innate immunity, and the multiple roles of mA in regulating specific viral infections. We also summarize the recent studies on mA during SARS-CoV-2 infection, focusing on points of convergence and divergence. Ultimately, this review provides a snapshot of the latest research on mA during viral infection.
N6-甲基腺苷（m6A）的 RNA 修饰控制着 RNA 功能的许多方面，这些方面影响着包括病毒感染在内的生物学过程。在这篇综述中，我们重点介绍了最近的工作，这些工作加深了我们对 m6A 通过作用于病毒或细胞 mRNA 分子来调节病毒感染的多种机制的理解。我们关注的是新兴概念和理解，包括病毒感染如何改变 m6A 机制蛋白的定位和功能，m6A 如何调节抗病毒先天免疫，以及 m6A 在调节特定病毒感染中的多种作用。我们还总结了最近关于 SARS-CoV-2 感染期间 m6A 的研究，重点介绍了趋同和分歧点。最终，这篇综述提供了病毒感染期间 m6A 最新研究的快照。
