Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Department of Laboratory Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Ann Med. 2021 Dec;53(1):1370-1376. doi: 10.1080/07853890.2021.1966084.
To the best of our knowledge, the association of inflammatory parameters with hepatic hydatid disease (HD) has not been investigated in a single study. We aimed to evaluate the potential value of inflammatory indices in this disorder.
The retrospective study including 114 patients was performed from January 2016 to November 2019. Clinical characteristics and laboratory data for all participants were collected and analysed. The levels of inflammatory parameters were compared in the patient and control group, the predictive value of these inflammatory parameters was assessed by the logistic regression analysis and receiver operating characteristic curve, and differences between pre- and post-surgical operations were compared by pair tests.
Significantly higher levels of platelet distribution width (PDW), eosinophil percentage (EOS %), neutrophil to lymphocyte ratio (NLR), gamma-glutamyl transpeptidase to platelet ratio (GPR) and alkaline phosphatase to platelet ratio (APPR) and lower levels of platelet (PLT) and prognostic nutritional index (PNI) were observed in patients than in controls. Multivariate analyses showed that hydatid could induce the abnormal levels of these parameters, of which APPR and PNI had more obvious changes as compared to other parameters. The levels of PDW and APPR significantly decreased after surgical treatment.
Inflammatory parameters closely associated with the hepatic HD could be used in the evaluation of treatment as assistant indexes.KEY MESSAGEHydatid disease (HD) seriously endangers public health and economic development.Inflammatory parameters that are readily available and acceptable in routine clinical practice could be closely associated with HD.Inflammatory parameters could be used in the evaluation of disease development by combing with histological and radiological results in future studies.
据我们所知，尚未有研究在单一研究中调查炎症参数与肝包虫病（HD）之间的关系。我们旨在评估炎症指标在这种疾病中的潜在价值。
这项回顾性研究纳入了 2016 年 1 月至 2019 年 11 月期间的 114 名患者。收集并分析了所有参与者的临床特征和实验室数据。比较了患者组和对照组中炎症参数的水平，通过逻辑回归分析和受试者工作特征曲线评估这些炎症参数的预测价值，并通过配对检验比较术前和术后之间的差异。
与对照组相比，患者的血小板分布宽度（PDW）、嗜酸性粒细胞百分比（EOS%）、中性粒细胞与淋巴细胞比值（NLR）、γ-谷氨酰转肽酶与血小板比值（GPR）和碱性磷酸酶与血小板比值（APPR）水平显著升高，血小板（PLT）和预后营养指数（PNI）水平显著降低。多变量分析显示，包虫病可引起这些参数的异常水平，其中 APPR 和 PNI 的变化比其他参数更为明显。手术后 PDW 和 APPR 水平显著降低。
与肝 HD 密切相关的炎症参数可作为辅助指标用于评估治疗效果。
