Department of Cardio-Thoracic and Vascular Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via G. Massarenti, 9, 40138 Bologna, Italy.
Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital, London, UK.
Eur Heart J. 2021 Nov 1;42(41):4224-4240. doi: 10.1093/eurheartj/ehab546.
The growing population of women with heart disease of reproductive age has been associated with an increasing number of high-risk pregnancies. Pregnant women with heart disease are a very heterogeneous population, with different risks for maternal cardiovascular, obstetric, and foetal complications. Adverse cardiovascular events during pregnancy pose significant clinical challenges, with uncertainties regarding diagnostic and therapeutic approaches potentially compromising maternal and foetal health. This review summarizes best practice for the treatment of common cardiovascular complications during pregnancy, based on expert opinion, current guidelines, and available evidence. Topics covered include heart failure (HF), arrhythmias, coronary artery disease, aortic and thromboembolic events, and the management of mechanical heart valves during pregnancy. Cardiovascular pathology is the leading cause of non-obstetric morbidity and mortality during pregnancy in developed countries. For women with pre-existing cardiac conditions, preconception counselling and structured follow-up during pregnancy are important measures for reducing the risk of acute cardiovascular complications during gestation and at the time of delivery. However, many women do not receive pre-pregnancy counselling often due to gaps in what should be lifelong care, and physicians are increasingly encountering pregnant women who present acutely with cardiac complications, including HF, arrhythmias, aortic events, coronary syndromes, and bleeding or thrombotic events. This review provides a summary of recommendations on the management of acute cardiovascular complication during pregnancy, based on available literature and expert opinion. This article covers the diagnosis, risk stratification, and therapy and is organized according to the clinical presentation and the type of complication, providing a reference for the practicing cardiologist, obstetrician, and acute medicine specialist, while highlighting areas of need and potential future research.
生育年龄的女性心脏病患者数量不断增加,这与高危妊娠的数量增加有关。患有心脏病的孕妇是一个非常异质的人群,其母体心血管、产科和胎儿并发症的风险不同。怀孕期间不良的心血管事件带来了重大的临床挑战,诊断和治疗方法的不确定性可能会损害母婴健康。
本综述基于专家意见、当前指南和现有证据,总结了治疗怀孕期间常见心血管并发症的最佳实践。涵盖的主题包括心力衰竭(HF)、心律失常、冠状动脉疾病、主动脉和血栓栓塞事件以及怀孕期间机械心脏瓣膜的管理。心血管疾病是发达国家孕妇非产科发病率和死亡率的主要原因。对于患有预先存在的心脏疾病的女性,妊娠前咨询和妊娠期间的结构化随访是降低妊娠期间和分娩时急性心血管并发症风险的重要措施。然而,由于终身护理方面存在差距,许多女性通常没有接受妊娠前咨询,而且越来越多的医生遇到了患有急性心血管并发症的孕妇,包括心力衰竭、心律失常、主动脉事件、冠状动脉综合征以及出血或血栓形成事件。
本综述根据现有文献和专家意见,提供了怀孕期间急性心血管并发症管理的建议摘要。本文涵盖了诊断、风险分层和治疗,并根据临床表现和并发症类型进行了组织,为执业心脏病专家、产科医生和急性医学专家提供了参考,同时强调了需要关注的领域和潜在的未来研究方向。