Grundmann R, Tübergen D
Chirurgische Universitätsklinik Köln-Lindenthal.
Infusionsther Klin Ernahr. 1987 Dec;14(6):284-8.
367 patients treated on the intensive care unit were prospectively documented during a 1-year observation period. Plasma colloid osmotic pressure (COP) was daily measured. Human albumin therapy was required only in 10% of all patients. These mainly long-term (greater than 10 days) treated patients also showed the lowest levels of COP (minimum COP means: 21 cmH2O (= 15.4 mmHg]. In the majority of all cases an extreme decrease of COP (less than 20 cmH2O (= 14.7 mmHg] was due to sepsis associated with an unfavorable prognosis. 67% of all patients with at least a single decrease of COP less than 20 cmH2O died, as compared to 15% of the patients where the COP never fell below 25 cmH2O. When a low COP was secondary to sepsis, the therapeutic benefit of an albumin therapy could not be evaluated.
在1年的观察期内，对重症监护病房治疗的367例患者进行了前瞻性记录。每天测量血浆胶体渗透压（COP）。仅10%的患者需要人血白蛋白治疗。这些主要是长期（超过10天）治疗的患者，其COP水平也最低（最低COP平均值：21cmH₂O（=15.4mmHg））。在大多数情况下，COP极度降低（低于20cmH₂O（=14.7mmHg））是由于伴有不良预后的脓毒症。与COP从未低于25cmH₂O的患者中的15%相比，所有COP至少有一次降低至低于20cmH₂O的患者中有67%死亡。当低COP继发于脓毒症时，无法评估白蛋白治疗的疗效。
