Black D W, Winokur G, Nasrallah A
Department of Psychiatry, University of Iowa College of Medicine.
Int J Psychiatry Med. 1987;17(4):351-60. doi: 10.2190/vl1b-7yee-91j5-mwra.
Mortality data are presented from a two to fourteen year follow-up of 705 primary unipolar depressives, 302 secondary unipolar depressives, and 586 patients with bipolar affective disorder (BAD) hospitalized at a tertiary care facility. Death ascertainment was made through a record-linkage process. Using sex- and age-standardized mortality ratios (SMRs), the mortality experience of the study population was compared with that of Iowa, the geographical area served by the admitting medical facility for this study group. Results show that risk for all-cause mortality was most pronounced during the first two years following hospital discharge, although secondary unipolar depressives continued to show a significant excess of deaths throughout the entire follow-up period. Deaths occurring from natural causes were significantly excessive only during the initial portion of the follow-up. Deaths from unnatural causes were significantly excessive throughout follow-up except for patients with bipolar affective disorder.
本文呈现了对705例原发性单相抑郁症患者、302例继发性单相抑郁症患者以及586例双相情感障碍（BAD）患者在一家三级医疗保健机构住院后进行的为期2至14年随访的死亡率数据。死亡情况通过记录链接过程确定。使用性别和年龄标准化死亡率（SMR），将研究人群的死亡经历与爱荷华州（本研究组收治医疗机构所服务的地理区域）的情况进行比较。结果显示，全因死亡率风险在出院后的头两年最为明显，尽管继发性单相抑郁症患者在整个随访期间的死亡人数仍持续显著过多。自然原因导致的死亡仅在随访初期显著过多。除双相情感障碍患者外，非自然原因导致的死亡在整个随访期间均显著过多。
