Tsuang M T, Woolson R F
Br J Psychiatry. 1977 Feb;130:162-6. doi: 10.1192/bjp.130.2.162.
Mortality data are presented from a four-decade follow-up study of 200 schizophrenic, 100 manic, 225 depressive patients, and 160 surgical controls (80 appendicectomy; 80 herniorrhaphy). Data for this analysis were available on 648 (95 per cent) members of the study population. Using sex-age standardized mortality ratios (SMR), the mortality experience of the study population was compared with that of the state of Iowa, the geographical area served by the admitting medical facility for the study group. Results are presented for a four-decade period beginning 1935-44, and ending 1965-74. All three psychiatric groups had a significant increase in mortality risk. This was most pronounced in the first decade following admission, although schizophrenic patients, especially females, continued to show a significant excess of deaths throughout the entire four decades of the follow-up period. During no decade of the follow-up period did the mortality of the surgical controls differ significantly from that of the Iowa population.
死亡率数据来自一项对200名精神分裂症患者、100名躁狂症患者、225名抑郁症患者以及160名外科手术对照组（80例阑尾切除术；80例疝修补术）进行的长达四十年的随访研究。该分析的数据来自研究人群中的648名成员（95%）。使用性别年龄标准化死亡率（SMR），将研究人群的死亡经历与爱荷华州（研究组收治医疗机构所在的地理区域）的死亡经历进行比较。结果呈现的是从1935 - 1944年开始至1965 - 1974年结束的四十年期间的情况。所有三个精神疾病组的死亡风险均显著增加。这在入院后的第一个十年最为明显，不过精神分裂症患者，尤其是女性，在整个四十年的随访期间死亡人数仍持续显著过多。在随访期间的任何十年中，外科手术对照组的死亡率与爱荷华州人群的死亡率均无显著差异。
