吲哚美辛对三叉神经诱发的副交感神经输出没有影响。
Indomethacin has no effect on trigeminally provoked parasympathetic output.
机构信息
Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany.
Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
出版信息
Cephalalgia. 2022 Jan;42(1):37-43. doi: 10.1177/03331024211030901. Epub 2021 Aug 18.
BACKGROUND
Unlike other non-steroidal anti-inflammatory drugs, indomethacin has been shown to be highly effective in two forms of trigeminal autonomic cephalalgias, hemicrania continua and paroxysmal hemicrania and in some forms of idiopathic stabbing headaches. This specificity is unique in the headache field. Previous findings suggest the involvement of the trigeminal autonomic reflex to play an important role in the pathophysiology of these diseases.
METHODS
22 healthy participants were enrolled in a double-blind, three-day within-subject design. The participants received indomethacin, ibuprofen or placebo in a randomized order. After an incubation period of 65 min the baseline lacrimation and the lacrimation during intranasal stimulation evoked by kinetic oscillation stimulation were assessed using Schirmer II lacrimation tests. The lacrimation difference in mm was calculated and compared in a repeated measures ANOVA.
RESULTS
No significant differences were found between the three conditions.
CONCLUSION
In our study, neither indomethacin nor ibuprofen had an inhibitory effect on the trigeminal autonomic reflex. We suggest that blocking this reflex may not be the treatment mechanism of indomethacin.
背景
与其他非甾体抗炎药不同，吲哚美辛已被证明在两种三叉神经自主头痛，即连续性偏头痛和阵发性偏头痛，以及某些类型的特发性刺痛性头痛中非常有效。这种特异性在头痛领域是独一无二的。先前的研究结果表明，三叉神经自主反射的参与在这些疾病的病理生理学中起着重要作用。
方法
22 名健康参与者被纳入一项双盲、三天内的个体设计研究。参与者以随机顺序接受吲哚美辛、布洛芬或安慰剂。在孵育期 65 分钟后，使用 Schirmer II 泪液测试评估基础流泪和动力学振荡刺激诱发的鼻内刺激时的流泪。通过重复测量方差分析计算并比较毫米的流泪差异。
结果
三种情况下均未发现显著差异。
结论
在我们的研究中，吲哚美辛和布洛芬均对三叉神经自主反射没有抑制作用。我们认为，阻断这种反射可能不是吲哚美辛的治疗机制。
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