McMahon F G, Ryan J R, Jain A K, LaCorte W, Ginzler F
Tulane University School of Medicine, New Orleans, LA.
J Antimicrob Chemother. 1987 Dec;20(6):913-8. doi: 10.1093/jac/20.6.913.
Disulfiram-type reactions after ingestion of alcohol have been reported in patients treated with a number of cephalosporin antibiotics; predominantly with agents containing the methylthiotetrazole side chain, although other similar configurations have also been implicated. Since cefonicid has a sulphonic acid thiotetrazole substitution, we investigated the possibility of a cefonicid-ethanol interaction in 15 healthy volunteers. During the first two crossover phases of the study, single 1 g doses of cefonicid followed by ethanol challenges were compared to placebo followed by ethanol challenges. In the third phase, all volunteers received three consecutive 1 g doses of cefonicid given at 24 h intervals followed by an ethanol challenge. At no time did any of the subjects experience a disulfiram-type reaction, and their blood aldehyde concentrations did not increase throughout the study.
据报道，使用多种头孢菌素抗生素治疗的患者在摄入酒精后会出现双硫仑样反应；主要是含有甲硫四氮唑侧链的药物，不过其他类似结构也有相关报道。由于头孢尼西有磺酸硫代四氮唑取代基，我们对15名健康志愿者进行了头孢尼西与乙醇相互作用可能性的研究。在研究的前两个交叉阶段，将单次1克剂量的头孢尼西后进行乙醇激发试验与安慰剂后进行乙醇激发试验进行了比较。在第三阶段，所有志愿者连续三天每隔24小时接受1克剂量的头孢尼西，随后进行乙醇激发试验。在整个研究过程中，没有任何一名受试者出现双硫仑样反应，他们的血液醛浓度也没有升高。
