Marcon G, Spolaor A, Scevola M, Zolli M, Carlassara G B
Divisione di Medicina generale, ULSS 17 Veneto, Ospedale, Mirano.
Recenti Prog Med. 1990 Jan;81(1):47-8.
The disulfiram-like reaction is linked to the assumption of ethyl alcohol during therapy with the cephalosporin latamoxef, cefamandole and cefoperazone. The reaction is commonly ascribed to the methyl-thiotetrazole group, resembling part of the disulfiram molecule. We describe the case of a patient who experienced on two different occasions a disulfiram-like effect during therapy with cefonicid. This cephalosporin contains the methylsulphothiotetrazole group in place of the methylthiotetrazole group. Our observation is the first related to cefonicid.
双硫仑样反应与在使用头孢菌素拉氧头孢、头孢孟多和头孢哌酮治疗期间摄入乙醇有关。该反应通常归因于甲基四氮唑基团，其类似于双硫仑分子的一部分。我们描述了一例患者在使用头孢尼西治疗期间两次出现双硫仑样效应的病例。这种头孢菌素含有甲基磺基四氮唑基团以取代甲基四氮唑基团。我们的观察是首例与头孢尼西相关的报道。
