Vidgen Miranda E, Williamson Dayna, Cutler Katrina, McCafferty Claire, Ward Robyn L, McNeil Keith, Waddell Nicola, Bunker David
QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.
Queensland Genomics, Queensland Health, Herston, QLD, Australia.
NPJ Genom Med. 2021 Aug 18;6(1):71. doi: 10.1038/s41525-021-00234-4.
The establishment of genomics in health care systems has been occurring for the past decade. It is recognised that implementing genomics within a health service is challenging without a system-wide approach. Globally, as clinical genomics implementation programs have matured there is a growing body of information around program design and outcomes. Program structures vary depending on local ecosystems including the health system, politics and funding availability, however, lessons from other programs are important to the design of programs in different jurisdictions. Here we describe an adaptive approach to the implementation of genomics into a publicly funded health care system servicing a population of 5.1 million people. The adaptive approach enabled flexibility to facilitate substantial changes during the program in response to learnings and external factors. We report the benefits and challenges experienced by the program, particularly in relation to the engagement of people and services, and the design of both individual projects and the program as a whole.
在过去十年中，基因组学已在医疗保健系统中逐步确立。人们认识到，在缺乏全系统方法的情况下，在医疗服务中实施基因组学具有挑战性。在全球范围内，随着临床基因组学实施项目的成熟，围绕项目设计和成果的信息越来越多。项目结构因当地生态系统而异，包括卫生系统、政治和资金可用性，然而，其他项目的经验教训对不同司法管辖区项目的设计很重要。在此，我们描述了一种将基因组学应用于为510万人口提供服务的公共资助医疗保健系统的适应性方法。这种适应性方法具有灵活性，能够在项目期间根据经验教训和外部因素促进重大变革。我们报告了该项目所经历的益处和挑战，特别是在人员和服务的参与以及单个项目和整个项目的设计方面。
