Nair S Vinod, Thomas Gigi, Ankathil Ravindran
Department of Oral and Maxillofacial Surgery, P.M.S Dental College, Vattapara, Trivandrum, India.
Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Chennai, India.
J Maxillofac Oral Surg. 2021 Sep;20(3):340-344. doi: 10.1007/s12663-020-01462-4. Epub 2020 Oct 16.
In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.
Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths. An assortment of genomic abnormalities can be screened at the same time, for example common and uncommon variations, auxiliary variations like insertions and deletions, copy-number variation, and fusion transcripts.
NGS innovations together with bioinformatics investigation, which extend our insight, are progressively used to analyze multiple genes in a cost-effective way and have been applied in examining clinical cancer samples and offering NGS-based molecular diagnosis.
NGS is progressively significant as a device for the diagnosis of cancers.
在本文中，我们提供了关于下一代测序（NGS）技术及其在癌症研究和分子诊断中的应用的整体概念。
DNA测序和RNA测序等下一代测序（NGS）技术的进步使得能够揭示个体恶性肿瘤的基因组、转录组和表观基因组情况。可以同时筛选多种基因组异常，例如常见和罕见变异、插入和缺失等结构变异、拷贝数变异以及融合转录本。
NGS创新技术与生物信息学分析相结合，拓展了我们的认知，越来越多地被用于以具有成本效益的方式分析多个基因，并已应用于检测临床癌症样本以及提供基于NGS的分子诊断。
NGS作为癌症诊断工具正变得越来越重要。
