Chioncel Valentin, Andrei Catalina Liliana, Brezeanu Radu, Sinescu Crina, Avram Anamaria, Tatu Alin Laurentiu
Department of Cardio-Thoracic Pathology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, 050474, Romania.
Medical and Pharmaceutical Research Unit/Competitive, Interdisciplinary Research Integrated Platform "Dunărea de Jos", ReForm-UDJG, Research Centre in the Field of Medical and Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Clinical Medical Department, "Dunărea de Jos" University of Galati, Galati, 800010, Romania.
Int J Gen Med. 2021 Aug 10;14:4327-4336. doi: 10.2147/IJGM.S326679. eCollection 2021.
The development of coronary stents has represented a revolution in the treatment of coronary heart disease. Beyond their many advantages, stents also have their limitations and complications. Allergic reactions to coronary stents are more common than acknowledged. These stented patients are exposed to foreign substances inserted in direct contact with the coronary intima. Hypersensitivity to stent components and drugs prescribed after stent insertion together with any environmental exposure seem to contribute to these adverse reactions. Patients can present to the hospital with a wide range of symptoms and multiple complications, the most important ones being instent restenosis and stent thrombosis. Although not very common (and not always easy to identify), allergic reactions after coronary or peripheral stents should be taken into account. Careful selection of patients (for elective stent implantation) depending on the propensity to allergies, although hard to achieve, represents a key factor in reducing the number of these complications.
冠状动脉支架的发展代表了冠心病治疗领域的一场革命。除了诸多优点外，支架也有其局限性和并发症。对冠状动脉支架的过敏反应比人们所认识到的更为常见。这些置入支架的患者接触到直接与冠状动脉内膜接触的外来物质。对支架组件及支架置入后所开药物的过敏反应，再加上任何环境暴露，似乎都促成了这些不良反应。患者可能会因各种症状和多种并发症前来就医，其中最重要的是支架内再狭窄和支架血栓形成。尽管冠状动脉或外周支架置入后的过敏反应并不十分常见（且并非总是易于识别），但仍应予以考虑。根据过敏倾向仔细挑选患者（进行择期支架植入），尽管难以做到，但却是减少此类并发症数量的关键因素。
