Svedman Cecilia, Ekqvist Susanne, Möller Halvor, Björk Jonas, Pripp Carl-Magnus, Gruvberger Birgitta, Holmström Eva, Gustavsson Carl-Gunnar, Bruze Magnus
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden.
Contact Dermatitis. 2009 Mar;60(3):158-64. doi: 10.1111/j.1600-0536.2008.01502.x.
Metallic implants, stents, are increasingly being used especially in patients with stenosis of the cardiac vessels. Ten to thirty per cent of the patients suffer from restenosis regardless of aetiology. We have shown increased frequency of contact allergy to stent metals in stented patients.
To we evaluate whether contact allergy to stent material is a risk factor for restenosis.
Patients with stainless steel stents, with or without gold plating, were epicutaneously tested and answered a questionnaire. The restenosis rate was evaluated.
We found a correlation between contact allergy to gold, gold stent, and restenosis (OR 2.3, CI 1.0-5.1, P = 0.04). The risk for restenosis was threefold increased when the patient was gold allergic and stented with a gold-plated stent. An increased degree of chest pain in gold-allergic patients stented with gold-plated stent was found.
We found a correlation between contact allergy to gold, gold-stent, and restenosis. It may be of importance to consider contact allergy when developing new materials for stenting.
金属植入物，即支架，越来越多地被应用，尤其是在患有心血管狭窄的患者中。无论病因如何，10%至30%的患者会发生再狭窄。我们已经表明，置入支架的患者对支架金属发生接触性过敏的频率有所增加。
我们评估对支架材料的接触性过敏是否是再狭窄的一个危险因素。
对有或没有镀金的不锈钢支架患者进行表皮试验并回答一份问卷。评估再狭窄率。
我们发现对金、金支架的接触性过敏与再狭窄之间存在相关性（比值比2.3，可信区间1.0 - 5.1，P = 0.04）。当患者对金过敏并置入镀金支架时，再狭窄风险增加了两倍。发现在置入镀金支架的金过敏患者中胸痛程度加重。
我们发现对金、金支架的接触性过敏与再狭窄之间存在相关性。在开发用于支架的新材料时考虑接触性过敏可能很重要。
