Glick Itamar, Kadish Ela, Rottenstreich Misgav
Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Int J Womens Health. 2021 Aug 10;13:751-759. doi: 10.2147/IJWH.S283216. eCollection 2021.
Pregnancy at advanced maternal age (age >35 years old) is considered a risk factor for adverse maternal and perinatal outcomes. Yet, pregnancies of advanced maternal age have become more prevalent over the last few decades. Possible maternal complications of pregnancy at age 35 or older include increased risk of spontaneous miscarriage, preterm labor, gestational diabetes mellitus, pre-eclampsia, stillbirth, chromosomal abnormalities, and cesarean delivery. Possible adverse fetal outcomes include infants small for gestational age and intrauterine growth restrictions, low Apgar score, admission to neonatal intensive care units, and an autism spectrum disorder. This paper aims to present an up-to-date review of the literature, summarizing the most current studies and implications for the management of pregnancy of advanced maternal age.
高龄孕产妇（年龄>35岁）怀孕被认为是孕产妇和围产期不良结局的一个风险因素。然而，在过去几十年中，高龄孕产妇怀孕变得更加普遍。35岁及以上孕妇可能出现的母体并发症包括自然流产、早产、妊娠期糖尿病、先兆子痫、死产、染色体异常和剖宫产的风险增加。可能的不良胎儿结局包括小于胎龄儿和宫内生长受限、阿氏评分低、入住新生儿重症监护病房以及自闭症谱系障碍。本文旨在对文献进行最新综述，总结最新研究以及对高龄孕产妇妊娠管理的启示。
