Paediatric Immunology and Vaccinology Unit, Division of General Paediatrics, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Centre for Vaccinology and Neonatal Immunology, Department of Paediatrics and Pathology-Immunology, Medical Faculty and University Hospitals of Geneva, Geneva, Switzerland.
Front Immunol. 2021 Aug 2;12:711637. doi: 10.3389/fimmu.2021.711637. eCollection 2021.
Children with autoimmune disorders are especially at risk of vaccine-preventable diseases due to their underlying disease and the immunosuppressive treatment often required for a long period. In addition, vaccine coverage remains too low in this vulnerable population. This can be explained by a fear of possible adverse effects of vaccines under immunosuppression, but also a lack of data and clear recommendations, particularly with regard to vaccination with live vaccines. In this review, the latest literature and recommendations on vaccination in immunosuppressed children are discussed in detail, with the aim to provide a set of practical guidelines on vaccination for specialists caring for children suffering from different autoimmune disorders and treated with various immunosuppressive regimens.
患有自身免疫性疾病的儿童由于其潜在疾病和长期所需的免疫抑制治疗，特别容易感染可通过疫苗预防的疾病。此外，该脆弱人群的疫苗接种覆盖率仍然过低。这可能是由于对免疫抑制下疫苗可能产生的不良反应的担忧，但也缺乏数据和明确的建议，尤其是关于活疫苗接种的建议。在这篇综述中，详细讨论了关于免疫抑制儿童接种疫苗的最新文献和建议，旨在为治疗不同自身免疫性疾病和使用各种免疫抑制方案的儿童的专家提供一套实用的疫苗接种指南。
