Department of Biotechnology, GLA University, Mathura, 281406, Uttar Pradesh, India.
Mol Biol Rep. 2023 Nov;50(11):9663-9676. doi: 10.1007/s11033-023-08809-3. Epub 2023 Oct 12.
As far as health issues are concerned, cancer causes one out of every six deaths around the globe. As potent therapeutics are still awaited for the successful treatment of cancer, some unconventional treatments like radiotherapy, surgery, and chemotherapy and some advanced technologies like gene therapy, stem cell therapy, natural antioxidants, targeted therapy, photodynamic therapy, nanoparticles, and precision medicine are available to diagnose and treat cancer. In the present scenario, the prime focus is on developing efficient nanomedicines to treat cancer. Although stem cell therapy has the capability to target primary as well as metastatic cancer foci, it also has the ability to repair and regenerate injured tissues. However, nanoparticles are designed to have such novel therapeutic capabilities. Targeted therapy is also now available to arrest the growth and development of cancer cells without damaging healthy tissues. Another alternative approach in this direction is photodynamic therapy (PDT), which has more potential to treat cancer as it does minimal damage and does not limit other technologies, as in the case of chemotherapy and radiotherapy. The best possible way to treat cancer is by developing novel therapeutics through translational research. In the present scenario, an important event in modern oncology therapy is the shift from an organ-centric paradigm guiding therapy to complete molecular investigations. The lacunae in anticancer therapy may be addressed through the creation of contemporary and pertinent cancer therapeutic techniques. In the meantime, the growth of nanotechnology, material sciences, and biomedical sciences has revealed a wide range of contemporary therapies with intelligent features, adaptable functions, and modification potential. The development of numerous therapeutic techniques for the treatment of cancer is summarized in this article. Additionally, it can serve as a resource for oncology and immunology researchers.
就健康问题而言，癌症是导致全球每六例死亡的原因之一。由于尚未找到有效的治疗癌症的疗法，一些非常规的治疗方法，如放射疗法、手术和化学疗法，以及一些先进的技术，如基因疗法、干细胞疗法、天然抗氧化剂、靶向疗法、光动力疗法、纳米粒子和精准医学，可用于诊断和治疗癌症。在当前情况下，主要重点是开发有效的纳米药物来治疗癌症。虽然干细胞疗法有能力靶向原发性和转移性癌症病灶，但它也有能力修复和再生受损组织。然而，纳米粒子被设计具有这种新颖的治疗能力。靶向疗法现在也可用于阻止癌细胞的生长和发育，而不会损害健康组织。在这方面的另一种替代方法是光动力疗法（PDT），它具有更大的治疗癌症的潜力，因为它造成的损害最小，并且不会像化学疗法和放射疗法那样限制其他技术。通过转化研究开发新的疗法是治疗癌症的最佳方法。在当前情况下，现代肿瘤学治疗中的一个重要事件是从指导治疗的器官中心范式转变为完整的分子研究。通过创建当代相关的癌症治疗技术，可以解决抗癌治疗中的空白。与此同时，纳米技术、材料科学和生物医学科学的发展揭示了一系列具有智能功能、适应性功能和修改潜力的当代疗法。本文总结了用于治疗癌症的多种治疗技术的发展。此外，它可以作为肿瘤学和免疫学研究人员的资源。
