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Real-World Effectiveness of Omalizumab in Severe Allergic Asthma: A Meta-Analysis of Observational Studies.奥马珠单抗治疗重度过敏性哮喘的真实世界疗效：一项观察性研究的荟萃分析。
J Allergy Clin Immunol Pract. 2021 Jul;9(7):2702-2714. doi: 10.1016/j.jaip.2021.01.011. Epub 2021 Jan 21.
2
Real-World Effectiveness of Benralizumab in Severe Eosinophilic Asthma.贝那鲁肽在重度嗜酸性哮喘中的真实世界疗效。
Chest. 2021 Feb;159(2):496-506. doi: 10.1016/j.chest.2020.08.2083. Epub 2020 Aug 31.
3
Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis.真实世界中美泊利单抗在前瞻性重度哮喘 REALITI-A 研究中的应用：初步分析。
Eur Respir J. 2020 Oct 15;56(4). doi: 10.1183/13993003.00151-2020. Print 2020 Oct.
4
Comparison of Artificial Intelligence-Based Fully Automatic Chest CT Emphysema Quantification to Pulmonary Function Testing.基于人工智能的全自动 CT 肺气肿定量与肺功能测试的比较。
AJR Am J Roentgenol. 2020 May;214(5):1065-1071. doi: 10.2214/AJR.19.21572. Epub 2020 Mar 4.
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Protocol of a Randomized Controlled Study of the PneumRx Endobronchial Coil System versus Standard-of-Care Medical Management in the Treatment of Subjects with Severe Emphysema (ELEVATE).随机对照研究方案：PneumRx 支气管内线圈系统与标准医疗管理治疗严重肺气肿患者的对照（ELEVATE）。
Respiration. 2019;98(6):512-520. doi: 10.1159/000502100. Epub 2019 Nov 19.
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Characteristics and treatment regimens across ERS SHARP severe asthma registries.欧洲呼吸学会严重哮喘注册研究中的特征及治疗方案
Eur Respir J. 2020 Jan 9;55(1). doi: 10.1183/13993003.01163-2019. Print 2020 Jan.
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Anti-IL-5 therapy in patients with severe eosinophilic asthma - clinical efficacy and possible criteria for treatment response.抗白细胞介素-5 疗法在严重嗜酸性粒细胞性哮喘患者中的临床疗效及可能的治疗反应标准。
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Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.度普利尤单抗在中重度未控制哮喘中的疗效和安全性。
N Engl J Med. 2018 Jun 28;378(26):2486-2496. doi: 10.1056/NEJMoa1804092. Epub 2018 May 21.
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Asthma and smoking-induced airway disease without spirometric COPD.哮喘和吸烟引起的气道疾病，无 spirometric COPD。
Eur Respir J. 2017 May 1;49(5). doi: 10.1183/13993003.02061-2016. Print 2017 May.
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Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial.贝那鲁肽治疗高剂量吸入性皮质激素和长效β-agonists 控制不佳的严重哮喘患者的疗效和安全性（SIROCCO）：一项随机、多中心、安慰剂对照的 3 期临床试验。
Lancet. 2016 Oct 29;388(10056):2115-2127. doi: 10.1016/S0140-6736(16)31324-1. Epub 2016 Sep 5.

既往吸烟暴露和慢性阻塞性肺疾病合并症对重度哮喘患者单克隆抗体治疗反应的影响。

Impact of prior smoking exposure and COPD comorbidity on treatment response to monoclonal antibodies in patients with severe asthma.

作者信息

Morobeid Heba, Pizarro Carmen, Biener Leonie, Ulrich-Merzenich Gudrun, Kütting Daniel, Nickenig Georg, Skowasch Dirk

机构信息

Dept of Internal Medicine II - Pneumology/Cardiology, University Hospital Bonn, Bonn, Germany.

These authors contributed equally.

出版信息

ERJ Open Res. 2021 Aug 16;7(3). doi: 10.1183/23120541.00190-2021. eCollection 2021 Jul.

DOI:10.1183/23120541.00190-2021
PMID:34409092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8365141/
Abstract

https://bit.ly/3fYC8tC.

摘要

https://bit.ly/3fYC8tC. （此为链接，无法准确翻译其内容，保留原文链接形式）