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莱姆病疫苗的临床疗效：一项配对病例对照研究。

Clinical Effectiveness of Lyme Vaccine: A Matched Case-Control Study.

作者信息

Oliveira Carlos R, Massad Christopher, Shapiro Eugene D, Vazquez Marietta

机构信息

Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.

Department of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, Connecticut, USA.

出版信息

Open Forum Infect Dis. 2021 Apr 17;8(8):ofab142. doi: 10.1093/ofid/ofab142. eCollection 2021 Aug.

DOI:10.1093/ofid/ofab142
PMID:34409119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8364756/
Abstract

We conducted a matched case-control study to assess the effectiveness of Lyme vaccine (LYMErix) as it was used in clinical practice. We found ≥3 doses to be 71% effective against Lyme disease. This is the first study to show that the Lyme vaccine is effective in a real-world setting.

摘要

我们开展了一项配对病例对照研究，以评估临床实践中使用的莱姆病疫苗（LYMErix）的有效性。我们发现，接种≥3剂疫苗对莱姆病的预防有效率为71%。这是第一项表明莱姆病疫苗在实际应用中有效的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a15f/8364756/c9c605fb03af/ofab142f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a15f/8364756/c9c605fb03af/ofab142f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a15f/8364756/c9c605fb03af/ofab142f0001.jpg

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Clinical Effectiveness of Lyme Vaccine: A Matched Case-Control Study.莱姆病疫苗的临床疗效：一项配对病例对照研究。
Open Forum Infect Dis. 2021 Apr 17;8(8):ofab142. doi: 10.1093/ofid/ofab142. eCollection 2021 Aug.
2
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Bayesian Model Averaging to Account for Model Uncertainty in Estimates of a Vaccine's Effectiveness.贝叶斯模型平均法在考虑疫苗有效性估计中模型不确定性方面的应用

本文引用的文献

1
The novel Lyme borreliosis vaccine VLA15 shows broad protection against Borrelia species expressing six different OspA serotypes.新型莱姆病疫苗VLA15对表达六种不同OspA血清型的疏螺旋体物种具有广泛的保护作用。
PLoS One. 2017 Sep 1;12(9):e0184357. doi: 10.1371/journal.pone.0184357. eCollection 2017.
2
Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.莱姆病、人粒细胞无形体病和巴贝斯虫病的诊断、治疗与预防：综述
JAMA. 2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884.
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Geographic Distribution and Expansion of Human Lyme Disease, United States.
Clin Epidemiol. 2022 Oct 18;14:1167-1175. doi: 10.2147/CLEP.S378039. eCollection 2022.
美国人类莱姆病的地理分布与扩散
Emerg Infect Dis. 2015 Aug;21(8):1455-7. doi: 10.3201/eid2108.141878.
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Update on persistent symptoms associated with Lyme disease.莱姆病相关持续性症状的最新情况。
Curr Opin Pediatr. 2015 Feb;27(1):100-4. doi: 10.1097/MOP.0000000000000167.
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Borrelia burgdorferi (Lyme disease).伯氏疏螺旋体（莱姆病）。
Pediatr Rev. 2014 Dec;35(12):500-9. doi: 10.1542/pir.35-12-500.
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Clinical practice. Lyme disease.临床实践。莱姆病。
N Engl J Med. 2014 May 1;370(18):1724-31. doi: 10.1056/NEJMcp1314325.
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The rise and fall of the lyme disease vaccines: a cautionary tale for risk interventions in American medicine and public health.莱姆病疫苗的兴衰：美国医学和公共卫生风险干预的警示故事。
Milbank Q. 2012 Jun;90(2):250-77. doi: 10.1111/j.1468-0009.2012.00663.x.
8
Effectiveness of personal protective measures to prevent Lyme disease.个人防护措施预防莱姆病的有效性。
Emerg Infect Dis. 2008 Feb;14(2):210-6. doi: 10.3201/eid1402.070725.
9
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.莱姆病、人粒细胞无形体病和巴贝斯虫病的临床评估、治疗及预防：美国传染病学会临床实践指南
Clin Infect Dis. 2006 Nov 1;43(9):1089-134. doi: 10.1086/508667. Epub 2006 Oct 2.
10
The Lyme disease vaccine: conception, development, and implementation.
Ann Intern Med. 2000 Apr 18;132(8):661-8. doi: 10.7326/0003-4819-132-8-200004180-00009.