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Random brick model for drug transport across stratum corneum.

作者信息

Tojo K

机构信息

Controlled Drug Delivery Research Center, Rutgers University, College of Pharmacy, Piscataway, NJ 08855-0789.

出版信息

J Pharm Sci. 1987 Dec;76(12):889-91. doi: 10.1002/jps.2600761209.

Abstract

A model for drug permeation across the stratum corneum is developed to predict the effect of the physical configuration and chemical composition of the stratum corneum on the skin permeability of drugs. The experimental data of percutaneous absorption across different skin specimens are well interpreted by the present model.

摘要

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