Reveley A M, Reveley M A
Maudsley Hospital, Denmark Hill, London, U.K.
J Psychiatr Res. 1987;21(4):515-20. doi: 10.1016/0022-3956(87)90100-2.
Cerebral ventricular enlargement in schizophrenia may occur more often in the absence of a family history of the disorder, suggesting that it is related to some non-genetic component of aetiology. This paper shows the finding to be much more apparent in a group of twins than in a similar group of singletons. Previous studies have shown twins in general to have larger cerebral ventricles than non-twins; we suggest that it is the greater susceptibility of twins to obstetric complications that is responsible for both the larger cerebral ventricles found in normal twins, and the very marked increase in ventricular size found in family history negative schizophrenic twins. We go on to consider evidence relating to a possible increased susceptibility of twins to develop schizophrenia.
精神分裂症患者的脑室扩大在无该疾病家族史的情况下可能更常出现，这表明它与病因学中的某些非遗传因素有关。本文显示，这一发现在一组双胞胎中比在一组类似的单胎中更为明显。先前的研究表明，一般来说双胞胎的脑室比非双胞胎的更大；我们认为，双胞胎对产科并发症的易感性更高，这既导致了正常双胞胎中发现的较大脑室，也导致了家族史阴性的精神分裂症双胞胎中脑室大小的显著增加。我们接着考虑与双胞胎患精神分裂症可能性增加相关的证据。
