Birong Dong, MD, Professor, Director, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang Renmin Nan Lu Chengdu, Sichuan, China, Fax: 86-28-85422321, 610041, Email address:
J Nutr Health Aging. 2021;25(7):903-908. doi: 10.1007/s12603-021-1642-2.
This study examined the relationship between cognitive performance and obesity parameters, such as body mass index (BMI), visceral fat area (VFA), waist circumference (WC), and waist-to-hip ratio (WHR) in western China.
A cross-sectional study.
3914 participants, aged ≥50 years, were recruited in this study. Anthropometrics measurements, life-style factors, chronic disease comorbidities, and sleep qualities were recorded for each participant. Among the anthropometrics, BMI, WC, and WHR were assessed using standard procedures, while VFA was calculated using bioelectrical impedance analysis. Cognitive performance was estimated using the Short Portable Mental Status Questionnaire (SPMSQ). Finally, relationships between cognitive abilities and BMI, VFA, WC, and WHR were evaluated using univariate and multivariate regression analyses.
Cognitive decline (CD) occurred at a rate of 13.29% among the 3914 participants. A strong correlation was observed between cognitive abilities and BMI of male patients aged 50-59 yrs (OR 1.116,95% CI1.002-1.242), in the adjusted model. Alternately, WHR was shown to be significantly related to CD in females aged ≥70 years (OR 0.041, 95% CI0.002-0.671). WC was shown to have a strong association with CD in males (OR 1.023,95% CI1.003-1.024). Lastly, WHR was closely connected to CD in participants with BMI < 25 kg/m2 (OR 0.022,95% CI0.002-0.209).
Our findings suggest that a higher middle age BMI is associated with CD, whereas, in the elderly population, a higher WHR is related to improved cognitive performance. Further investigation is warranted to elucidate a relationship between VFA and CD.
本研究旨在探讨认知表现与肥胖参数之间的关系，这些肥胖参数包括身体质量指数（BMI）、内脏脂肪面积（VFA）、腰围（WC）和腰臀比（WHR），研究对象来自中国西部地区。
一项横断面研究。
本研究共纳入 3914 名年龄≥50 岁的参与者。记录每位参与者的人体测量学测量值、生活方式因素、慢性疾病合并症和睡眠质量。在人体测量学中，使用标准程序评估 BMI、WC 和 WHR，而 VFA 则使用生物电阻抗分析进行计算。使用简易精神状态检查表（SPMSQ）评估认知表现。最后，使用单变量和多变量回归分析评估认知能力与 BMI、VFA、WC 和 WHR 之间的关系。
在 3914 名参与者中，有 13.29%的人出现认知能力下降（CD）。在调整模型中，年龄在 50-59 岁的男性患者中，认知能力与 BMI 呈强相关性（OR 1.116，95%CI1.002-1.242）。相反，在年龄≥70 岁的女性中，WHR 与 CD 显著相关（OR 0.041，95%CI0.002-0.671）。WC 与男性的 CD 有很强的关联（OR 1.023，95%CI1.003-1.024）。最后，在 BMI<25kg/m2 的参与者中，WHR 与 CD 密切相关（OR 0.022，95%CI0.002-0.209）。
我们的研究结果表明，中年 BMI 较高与 CD 相关，而在老年人群中，较高的 WHR 与认知表现改善相关。需要进一步的研究来阐明 VFA 与 CD 之间的关系。
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